1. Gene
  2. PCDHB16 - protocadherin beta 16 Gene

PCDHB16 - protocadherin beta 16 Gene

Homo sapiens

Also known as ME1; PCDH3X; PCDHB8a; PCDH-BETA16

Gene ID: 57717 | Gene type: protein coding

About PCDHB16

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,182,387-141,186,226 (from NCBI)

This gene has 2 transcripts (splice variants), 36 orthologues and 61 paralogues.

Summary

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from Others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]

PCDHB16 Products(1)

mRNA Protein Name
NM_020957.4 NP_066008.2 protocadherin beta-16 precursor

PCDHB16 Protein Structure

Cadherin_2

Cadherin_2: Cadherin-like (32 - 112)

Cadherin

Cadherin: Cadherin domain (141 - 232)

Cadherin

Cadherin: Cadherin domain (247 - 337)

Cadherin

Cadherin: Cadherin domain (356 - 441)

Cadherin

Cadherin: Cadherin domain (456 - 552)

Cadherin

Cadherin: Cadherin domain (580 - 661)

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  • 776 a.a.
Protein Preferred Names Protein Names

protocadherin beta-16

cadherin ME1

Related Diseases

Diseases Alias
Sciatic Neuropathy
Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Mononeuritis Of Lower Limb
Hypermobility Syndrome

Benign Joint Hypermobility

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCDHB16 RGD RGD:11492646
Mus musculus PCDHB16 MGD MGI:2136754