2. Gene
  3. RGS1 - regulator of G protein signaling 1 Gene

RGS1 - regulator of G protein signaling 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 1R20; BL34; IER1; IR20; HEL-S-87

Gene ID: 5996 | Gene type: protein coding

About RGS1

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,575,773-192,580,024 (from NCBI)

This gene has 6 transcripts (splice variants), 242 orthologues and 23 paralogues. Broad expression in appendix (RPKM 110.9), lymph node (RPKM 72.3) and 17 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

RGS1 Products(1)

mRNA Protein Name
NM_002922.4 NP_002913.3 regulator of G-protein signaling 1

RGS1 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (85 - 199)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 1

B-cell activation protein BL34

Related Diseases

Diseases Alias
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11902 RGS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RGS1 VGNC VGNC:45519
Bos taurus RGS1 VGNC VGNC:33910
Macaca mulatta RGS1 VGNC VGNC:76914
Felis catus RGS1 VGNC VGNC:107929
Rattus norvegicus RGS1 RGD RGD:3561
Mus musculus RGS1 MGD MGI:1354694
Others RGS1 NCBI