ARHGAP9 - Rho GTPase activating protein 9 Gene

Also Known as 10C; RGL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64333

About ARHGAP9

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,472,269-57,488,824 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 3 paralogues. Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues.

Summary

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP9 Products (11)

mRNA Protein Name
NM_001080156.3 NP_001073625.1 rho GTPase-activating protein 9 isoform 3
NM_001080157.2 NP_001073626.1 rho GTPase-activating protein 9 isoform 2
NM_001319850.2 NP_001306779.2 rho GTPase-activating protein 9 isoform 4
NM_001319851.2 NP_001306780.1 rho GTPase-activating protein 9 isoform 5
NM_001319852.2 NP_001306781.1 rho GTPase-activating protein 9 isoform 6
NM_001367422.1 NP_001354351.1 rho GTPase-activating protein 9 isoform 7
NM_001367423.1 NP_001354352.1 rho GTPase-activating protein 9 isoform 8
NM_001367424.1 NP_001354353.1 rho GTPase-activating protein 9 isoform 9
NM_001367425.1 NP_001354354.1 rho GTPase-activating protein 9 isoform 10
NM_001367426.1 NP_001354355.1 rho GTPase-activating protein 9 isoform 3
NM_032496.4 NP_115885.2 rho GTPase-activating protein 9 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
11396949 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
17339315 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP9 Protein Structure

SH3_1

SH3_1: SH3 domain (29 - 67)

PH

PH: PH domain (324 - 434)

RhoGAP

RhoGAP: RhoGAP domain (537 - 705)

  • 0
  • 200
  • 400
  • 600
  • 731 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 9

  • rho-type GTPase-activating protein 9

ARHGAP9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 GRB2 Homo sapiens P62993
Y2H Array
25416956
Intra
ARHGAP9 Q9BRR9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 FHL2 Homo sapiens Q14192
Y2H Array
25416956
Intra
ARHGAP9 Q9BRR9 MRPL38 Homo sapiens Q96DV4
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 MRPL38 Homo sapiens Q96DV4
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
Intra
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Y2H Array
32296183
Intra
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
32296183
Intra
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
ARHGAP9 Q9BRR9 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00942 ARHGAP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP9 VGNC VGNC:69826
Rattus norvegicus ARHGAP9 RGD RGD:1305342
Bos taurus ARHGAP9 VGNC VGNC:26100
Felis catus ARHGAP9 VGNC VGNC:59895
Mus musculus ARHGAP9 MGD MGI:2143764
Others ARHGAP9 NCBI