2. Gene
  3. ARHGAP9 - Rho GTPase activating protein 9 Gene

ARHGAP9 - Rho GTPase activating protein 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as 10C; RGL1

Gene ID: 64333 | Gene type: protein coding

About ARHGAP9

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,472,269-57,488,824 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 3 paralogues. Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues.

Summary

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP9 Products(11)

mRNA Protein Name
NM_001080156.3 NP_001073625.1 rho GTPase-activating protein 9 isoform 3
NM_001080157.2 NP_001073626.1 rho GTPase-activating protein 9 isoform 2
NM_001319850.2 NP_001306779.2 rho GTPase-activating protein 9 isoform 4
NM_001319851.2 NP_001306780.1 rho GTPase-activating protein 9 isoform 5
NM_001319852.2 NP_001306781.1 rho GTPase-activating protein 9 isoform 6
NM_001367422.1 NP_001354351.1 rho GTPase-activating protein 9 isoform 7
NM_001367423.1 NP_001354352.1 rho GTPase-activating protein 9 isoform 8
NM_001367424.1 NP_001354353.1 rho GTPase-activating protein 9 isoform 9
NM_001367425.1 NP_001354354.1 rho GTPase-activating protein 9 isoform 10
NM_001367426.1 NP_001354355.1 rho GTPase-activating protein 9 isoform 3
NM_032496.4 NP_115885.2 rho GTPase-activating protein 9 isoform 1

ARHGAP9 Protein Structure

SH3_1

SH3_1: SH3 domain (29 - 67)

PH

PH: PH domain (324 - 434)

RhoGAP

RhoGAP: RhoGAP domain (537 - 705)

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  • 731 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 9

rho-type GTPase-activating protein 9

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00942 ARHGAP9 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARHGAP9 VGNC VGNC:69826
Rattus norvegicus ARHGAP9 RGD RGD:1305342
Bos taurus ARHGAP9 VGNC VGNC:26100
Felis catus ARHGAP9 VGNC VGNC:59895
Mus musculus ARHGAP9 MGD MGI:2143764