TAF2 - TATA-box binding protein associated factor 2 Gene

Homo sapiens

Also known as MRT40; TAF2B; CIF150; TAFII150

Gene ID: 6873 | Gene type: protein coding

About TAF2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,730,774-119,832,841 (from NCBI)

This gene has 43 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

TAF2 Products(1)

mRNA	Protein	Name
NM_003184.4	NP_003175.2	transcription initiation factor TFIID subunit 2

TAF2 Protein Structure

Peptidase_M1

0
200
400
600
800
1000
1199 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 2

150 kDa cofactor of initiator function

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Feeding Difficulties, Thin Corpus Callosum, And Foot Deformity

Microcephaly-Thin Corpus Callosum-Intellectual Disability Syndrome	NEDFCF
Mrt40	Mental Retardation, Autosomal Recessive 40
Intellectual Developmental Disorder, Autosomal Recessive 40	Autosomal Recessive Intellectual Developmental Disorder 40
Mental Retardation, Autosomal Recessive, Type 40

Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism	DYT3
Xdp	Lubag
Dystonia-Parkinsonism, X-Linked	Torsion Dystonia-Parkinsonism, Filipino Type
Dyt-Taf1	X-Linked Dystonia-Parkinsonism Syndrome
X-Linked Torsion Dystonia-Parkinsonism Syndrome	Dystonia Musculorum Deformans
X-Linked Dystonia-Parkinsonism/Lubag	Lubag Syndrome
Dystonia-3	Torsion Dystonia-Parkinsonism Filipino Type
X-Linked Torsion Dystonia 3	Dystonia, Torsion, X-Linked, Type 3

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14167	TAF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAF2	MGD	MGI:2443028
Canis familiaris	TAF2	VGNC	VGNC:47080
Felis catus	TAF2	VGNC	VGNC:65930
Macaca mulatta	TAF2	VGNC	VGNC:78090
Rattus norvegicus	TAF2	RGD	RGD:621487
Bos taurus	TAF2	VGNC	VGNC:35573

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