TAF2 - TATA-box binding protein associated factor 2 Gene

Also Known as MRT40; TAF2B; CIF150; TAFII150

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6873

About TAF2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,730,774-119,832,841 (from NCBI)

This gene has 43 transcripts (splice variants), 207 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 6.4) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

TAF2 Products (1)

mRNA	Protein	Name
NM_003184.4	NP_003175.2	transcription initiation factor TFIID subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9418870	GOA
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	10409744	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10409744	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	9418870	GOA
involved in transcription initiation at RNA polymerase II promoter	IMP IMP: Inferred from mutant phenotype	10409744	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	9774672	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	10373431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF2 Protein Structure

Peptidase_M1

0
200
400
600
800
1000
1199 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 2	150 kDa cofactor of initiator function

TAF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAF2	Q6P1X5	PUF60	Homo sapiens	Q9UHX1-2	Validated Y2H	32296183
Intra	TAF2	Q6P1X5	PUF60	Homo sapiens	Q9UHX1-2	Y2H Array	32296183
Intra	TAF2	Q6P1X5	PUF60	Homo sapiens	Q9UHX1-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Feeding Difficulties, Thin Corpus Callosum, And Foot Deformity	Microcephaly-Thin Corpus Callosum-Intellectual Disability Syndrome NEDFCF Mrt40 Mental Retardation, Autosomal Recessive 40 Intellectual Developmental Disorder, Autosomal Recessive 40 Autosomal Recessive Intellectual Developmental Disorder 40 Mental Retardation, Autosomal Recessive, Type 40
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14167	TAF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAF2	MGD	MGI:2443028
Canis familiaris	TAF2	VGNC	VGNC:47080
Felis catus	TAF2	VGNC	VGNC:65930
Macaca mulatta	TAF2	VGNC	VGNC:78090
Rattus norvegicus	TAF2	RGD	RGD:621487
Bos taurus	TAF2	VGNC	VGNC:35573
Others	TAF2	NCBI