TAF7 - TATA-box binding protein associated factor 7 Gene

Also Known as TAF2F; TAFII55

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6879

About TAF7

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,318,490-141,320,784 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 1 paralogue.

Summary

The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and Other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

TAF7 Products (1)

mRNA	Protein	Name
NM_005642.3	NP_005633.2	transcription initiation factor TFIID subunit 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	7824954	GOA
contributes to H3K27me3 modified histone binding	IPI IPI: Inferred from physical interaction	24927529	GOA
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	18391197	GOA
contributes to RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9603525	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	7824954	GOA
enables TFIIH-class transcription factor complex binding	IDA IDA: Inferred from direct assay	18391197	GOA
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	11592977	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	10409738	GOA
enables nuclear vitamin D receptor binding	IPI IPI: Inferred from physical interaction	10409738	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7824954	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	25412659	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18391197	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	9603525	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11592977	GOA
involved in negative regulation of MHC class I biosynthetic process	IDA IDA: Inferred from direct assay	20937824	GOA
involved in negative regulation of MHC class II biosynthetic process	IMP IMP: Inferred from mutant phenotype	20937824	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	18391197	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16407123	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12676957	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7824954	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	29203640	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	7824954	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	9603525	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	25412659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF7 Protein Structure

TAFII55_N

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 7	RNA polymerase II TBP-associated factor subunit F

TAF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAF7	Q15545	UNG	Homo sapiens	P13051-2	Validated Y2H	32814053
Intra	TAF7	Q15545	UNG	Homo sapiens	P13051-2	Y2H Pooling	32814053
Intra	TAF7	Q15545	UNG	Homo sapiens	P13051-2	Y2H Array	32814053
Intra	TAF7	Q15545	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	TAF7	Q15545	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	TAF7	Q15545	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	TAF7	Q15545	PABIR3	Homo sapiens	Q6P4D5-2	Validated Y2H	32814053
Intra	TAF7	Q15545	PABIR3	Homo sapiens	Q6P4D5-2	Y2H Array	32814053
Intra	TAF7	Q15545	PABIR3	Homo sapiens	Q6P4D5-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14175	TAF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAF7	VGNC	VGNC:110430
Canis familiaris	TAF7	VGNC	VGNC:47087
Felis catus	TAF7	VGNC	VGNC:97652
Mus musculus	TAF7	MGD	MGI:1346348
Rattus norvegicus	TAF7	RGD	RGD:1309935
Bos taurus	TAF7	VGNC	VGNC:35579
Others	TAF7	NCBI