P2ry12 - purinergic receptor P2Y, G-protein coupled 12 Gene

Also Known as P2Y12; 2900079B22Rik; 4921504D23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70839

About P2ry12

Chromosome 3: 59,123,693-59,170,292 reverse strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 5 phenotypes. Broad expression in cortex adult (RPKM 1.9), frontal lobe adult (RPKM 1.2) and 15 other tissues.

Summary

Enables G protein-coupled ADP receptor activity and G protein-coupled Adenosine Receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of ion transport. Located in cell body membrane and cell projection membrane. Is expressed in central nervous system and cerebral cortex. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]

P2ry12 Products (4)

mRNA Protein Name
NM_001357010.1 NP_001343939.1 P2Y purinoceptor 12
NM_027571.4 NP_081847.3 P2Y purinoceptor 12
NM_001357008.1 NP_001343937.1 P2Y purinoceptor 12
NM_001357007.1 NP_001343936.1 P2Y purinoceptor 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled ADP receptor activity IMP
IMP: Inferred from mutant phenotype
11413167 MGI
enables G protein-coupled adenosine receptor activity IMP
IMP: Inferred from mutant phenotype
11413167 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11413167 MGI
involved in cellular response to ATP IMP
IMP: Inferred from mutant phenotype
17115040 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23479225 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
15914557 MGI
acts upstream of monoatomic ion transport IGI
IGI: Inferred from genetic interaction
15914557 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
11413167 MGI
acts upstream of or within positive regulation of monoatomic ion transport IGI
IGI: Inferred from genetic interaction
15914557 MGI
involved in regulation of microglial cell migration IDA
IDA: Inferred from direct assay
17115040 MGI
involved in substrate-dependent cell migration, cell extension IMP
IMP: Inferred from mutant phenotype
17115040 MGI
involved in visual system development IGI
IGI: Inferred from genetic interaction
26948129 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body membrane IGI
IGI: Inferred from genetic interaction
26948129 MGI
located in cell projection membrane IGI
IGI: Inferred from genetic interaction
26948129 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17115040 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry12 Protein Structure

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 314)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 58)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (64 - 89)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (102 - 132)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (144 - 166)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (191 - 220)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (240 - 268)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (281 - 305)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 12

P2ry12 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87002 P2Y12 Antibody (YA6695) IHC-F, IHC-P Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09919 P2RY12 Human Pre-designed siRNA Set A / Unkown
HY-RS09920 P2ry12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09921 P2ry12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2ry12 NCBI NCBI:64805