TTC1 - tetratricopeptide repeat domain 1 Gene

Also Known as TPR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7265

About TTC1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,009,139-160,065,543 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 29.2), heart (RPKM 23.5) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TTC1 Products (2)

mRNA	Protein	Name
NM_001282500.2	NP_001269429.1	tetratricopeptide repeat protein 1
NM_003314.3	NP_003305.1	tetratricopeptide repeat protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9383998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC1 Protein Structure

TPR_11

TPR_1

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
tetratricopeptide repeat protein 1	TPR repeat protein 1

TTC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	28514442
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	33961781
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Validated Y2H	32296183
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Y2H Array	32296183
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	25416956
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	25036637
Intra	TTC1	Q99614	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	32296183
Intra	TTC1	Q99614	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	TTC1	Q99614	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	TTC1	Q99614	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	TTC1	Q99614	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	TTC1	Q99614	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TTC1	Q99614	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TTC1	Q99614	CYB5R1	Homo sapiens	Q9UHQ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 75	RP75 Retinitis Pigmentosa, Type 75
Siberian Tick Typhus	North Asian Tick Typhus Manchurian Typhus North Asian Tick Fever Rickettsia Sibirica Spotted Fever Spotted Fever Group Rickettsiosis
Lipofibromatosis-Like Neural Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15195	TTC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21449	Ttc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27967	Ttc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TTC1	VGNC	VGNC:78667
Mus musculus	TTC1	MGD	MGI:1914077
Bos taurus	TTC1	VGNC	VGNC:36453
Felis catus	TTC1	VGNC	VGNC:66650
Canis familiaris	TTC1	VGNC	VGNC:47936
Rattus norvegicus	TTC1	RGD	RGD:1359604
Others	TTC1	NCBI