2. Gene
  3. TTC1 - tetratricopeptide repeat domain 1 Gene

TTC1 - tetratricopeptide repeat domain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TPR1

Gene ID: 7265 | Gene type: protein coding

About TTC1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,009,139-160,065,543 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 29.2), heart (RPKM 23.5) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TTC1 Products(2)

mRNA Protein Name
NM_001282500.2 NP_001269429.1 tetratricopeptide repeat protein 1
NM_003314.3 NP_003305.1 tetratricopeptide repeat protein 1

TTC1 Protein Structure

TPR_11

TPR_11: TPR repeat (118 - 186)

TPR_1

TPR_1: Tetratricopeptide repeat (191 - 221)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

tetratricopeptide repeat protein 1

TPR repeat protein 1

Related Diseases

Diseases Alias
Retinitis Pigmentosa 75

RP75

Retinitis Pigmentosa, Type 75
Siberian Tick Typhus

North Asian Tick Typhus

Manchurian Typhus

North Asian Tick Fever

Rickettsia Sibirica Spotted Fever

Spotted Fever Group Rickettsiosis
Lipofibromatosis-Like Neural Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15195 TTC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TTC1 VGNC VGNC:78667
Mus musculus TTC1 MGD MGI:1914077
Bos taurus TTC1 VGNC VGNC:36453
Felis catus TTC1 VGNC VGNC:66650
Canis familiaris TTC1 VGNC VGNC:47936
Rattus norvegicus TTC1 RGD RGD:1359604
Others TTC1 NCBI