country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

VIL1 - villin 1 Gene

Also Known as VIL; D2S1471

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7429

About VIL1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,419,123-218,453,295 (from NCBI)

This gene has 5 transcripts (splice variants), 166 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 141.0), duodenum (RPKM 126.6) and 3 other tissues.

Summary

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border Cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

VIL1 Products (1)

mRNA	Protein	Name
NM_007127.3	NP_009058.2	villin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	11500485	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	11500485	GOA
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	15272027	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17606613	GOA
enables lysophosphatidic acid binding	IDA IDA: Inferred from direct assay	19808673	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	14594952	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16921170	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17606613	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament capping	IDA IDA: Inferred from direct assay	16921170	GOA
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	11500485	GOA
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	11500485	GOA
involved in actin filament severing	IDA IDA: Inferred from direct assay	16921170	GOA
involved in barbed-end actin filament capping	IMP IMP: Inferred from mutant phenotype	15272027	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	17229814	GOA
involved in cytoplasmic actin-based contraction involved in cell motility	IDA IDA: Inferred from direct assay	15342783	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17229814	GOA
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in positive regulation of actin filament bundle assembly	IDA IDA: Inferred from direct assay	19808673	GOA
involved in positive regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	15272027	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	16921170	GOA
involved in positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	17229814	GOA
involved in positive regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	18054784	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	18054784	GOA
involved in positive regulation of lamellipodium morphogenesis	IGI IGI: Inferred from genetic interaction	18054784	GOA
involved in positive regulation of lamellipodium morphogenesis	IMP IMP: Inferred from mutant phenotype	18054784	GOA
involved in regulation of actin nucleation	IDA IDA: Inferred from direct assay	16921170	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	16921170	GOA
involved in response to bacterium	IDA IDA: Inferred from direct assay	17182858	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament bundle	IDA IDA: Inferred from direct assay	17182858	GOA
located in filopodium	IDA IDA: Inferred from direct assay	15342783	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	16921170	GOA
located in microvillus	IDA IDA: Inferred from direct assay	17182858	GOA
located in ruffle	IDA IDA: Inferred from direct assay	15342783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VIL1 Protein Structure

Gelsolin

VHP

0
200
400
600
827 a.a.

Protein Preferred Names	Protein Names
villin-1

VIL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VIL1	P09327	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	17229814
Intra	VIL1	P09327	VIL1	Homo sapiens	P09327	Density Sedimentation	17606613
Intra	VIL1	P09327	VIL1	Homo sapiens	P09327	Crosslink	17606613
Intra	VIL1	P09327	VIL1	Homo sapiens	P09327	GMS	17606613
Intra	VIL1	P09327	TEX11	Homo sapiens	Q8IYF3	Y2H Pooling	16189514
Intra	VIL1	P09327	VIL1	Homo sapiens	P09327	Pull Down	17606613
Intra	VIL1	P09327	VIL1	Homo sapiens	P09327	FRET	17606613
Intra	VIL1	P09327	PLCG1	Homo sapiens	P19174	FRET	17229814

Cross: Cross-species interaction Intra: Intraspecies interaction

VIL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80986	Villin Antibody (YA3548)	WB, IHC-P, IP	Human
HY-P84027	Villin Antibody (YA3724)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84027A	Villin Antibody (YA3724)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85781	Villin Antibody (YA5473)	WB, IHC-P	Human, Mouse, Rat
HY-P85967	Villin Antibody (YA5659)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Pig, Bovin,

Related Diseases

Diseases	Alias
Contagious Pustular Dermatitis	Ecthyma, Contagious Orf Ecthyma Contagiosum Scabby Mouth Sheep Pox Thistle Disease Contagious Pustular Dermatosis
Milker'S Nodule	Poxviridae Infections Milker Nodule Milkers' Node Paravaccinia Pseudocowpox Milker'S Nodes
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Spondyloepiphyseal Dysplasia, Nishimura Type	SEDN Spondyloepiphyseal Dysplasia Nishimura Type
Meckel Diverticulum	Meckel'S Diverticulum Persistent Vitelline Duct
Chemical Colitis
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15650	VIL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VIL1	MGD	MGI:98930
Rattus norvegicus	VIL1	RGD	RGD:1307048
Canis familiaris	VIL1	VGNC	VGNC:48261
Macaca mulatta	VIL1	VGNC	VGNC:78768
Felis catus	VIL1	VGNC	VGNC:66942
Bos taurus	VIL1	VGNC	VGNC:36794
Others	VIL1	NCBI