2. Gene
  3. TRIM46 - tripartite motif containing 46 Gene

TRIM46 - tripartite motif containing 46 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GENEY; TRIFIC

Gene ID: 80128 | Gene type: protein coding

About TRIM46

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,173,849-155,184,971 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 80 paralogues. Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues.

Summary

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of Cancer cells including lung and breast Cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

TRIM46 Products(9)

mRNA Protein Name
NM_001256599.2 NP_001243528.1 tripartite motif-containing protein 46 isoform 2
NM_001256601.1 NP_001243530.1 tripartite motif-containing protein 46 isoform 4
NM_001282378.2 NP_001269307.1 tripartite motif-containing protein 46 isoform 5
NM_001282379.2 NP_001269308.1 tripartite motif-containing protein 46 isoform 6
NM_001406245.1 NP_001393174.1 tripartite motif-containing protein 46 isoform 3
NM_001406246.1 NP_001393175.1 tripartite motif-containing protein 46 isoform 7
NM_001406247.1 NP_001393176.1 tripartite motif-containing protein 46 isoform 8
NM_001406256.1 NP_001393185.1 tripartite motif-containing protein 46 isoform 2
NM_025058.5 NP_079334.3 tripartite motif-containing protein 46 isoform 1

TRIM46 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (33 - 62)

zf-B_box

zf-B_box: B-box zinc finger (225 - 263)

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  • 759 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 46

gene Y protein

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 2

IBD2
Phosphoribosylpyrophosphate Synthetase Superactivity

PRPS1 SUPERACTIVITY

Prpp Synthetase Superactivity

Gout, Prps-Related

Prpp Synthetase Deficiency

Prpp Synthetase Overactivity

Prs Overactivity

Prs Superactivity

Mild Phosphoribosylpyrophosphate Synthetase Superactivity

Mild Prpp Synthetase Superactivity

Mild Prps1 Superactivity

Severe Phosphoribosylpyrophosphate Synthetase Superactivity

Severe Prpp Synthetase Superactivity

Severe Prps1 Superactivity

Prps-Related Gout

Superactivity, Phosphoribosylpyrophosphate Synthetase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15050 TRIM46 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRIM46 RGD RGD:1305993
Bos taurus TRIM46 VGNC VGNC:36338
Felis catus TRIM46 VGNC VGNC:66542
Mus musculus TRIM46 MGD MGI:2673000
Macaca mulatta TRIM46 VGNC VGNC:79170
Canis familiaris TRIM46 VGNC VGNC:47825