TRIM46 - tripartite motif containing 46 Gene

Also Known as GENEY; TRIFIC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80128

About TRIM46

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,173,849-155,184,971 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 80 paralogues. Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues.

Summary

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of Cancer cells including lung and breast Cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

TRIM46 Products (9)

mRNA	Protein	Name
NM_001256599.2	NP_001243528.1	tripartite motif-containing protein 46 isoform 2
NM_001256601.1	NP_001243530.1	tripartite motif-containing protein 46 isoform 4
NM_001282378.2	NP_001269307.1	tripartite motif-containing protein 46 isoform 5
NM_001282379.2	NP_001269308.1	tripartite motif-containing protein 46 isoform 6
NM_001406245.1	NP_001393174.1	tripartite motif-containing protein 46 isoform 3
NM_001406246.1	NP_001393175.1	tripartite motif-containing protein 46 isoform 7
NM_001406247.1	NP_001393176.1	tripartite motif-containing protein 46 isoform 8
NM_001406256.1	NP_001393185.1	tripartite motif-containing protein 46 isoform 2
NM_025058.5	NP_079334.3	tripartite motif-containing protein 46 isoform 1

TRIM46 Protein Structure

zf-C3HC4

zf-B_box

0
200
400
600
759 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 46	gene Y protein

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 2	IBD2
Phosphoribosylpyrophosphate Synthetase Superactivity	PRPS1 SUPERACTIVITY Prpp Synthetase Superactivity Gout, Prps-Related Prpp Synthetase Deficiency Prpp Synthetase Overactivity Prs Overactivity Prs Superactivity Mild Phosphoribosylpyrophosphate Synthetase Superactivity Mild Prpp Synthetase Superactivity Mild Prps1 Superactivity Severe Phosphoribosylpyrophosphate Synthetase Superactivity Severe Prpp Synthetase Superactivity Severe Prps1 Superactivity Prps-Related Gout Superactivity, Phosphoribosylpyrophosphate Synthetase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15050	TRIM46 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM46	RGD	RGD:1305993
Bos taurus	TRIM46	VGNC	VGNC:36338
Felis catus	TRIM46	VGNC	VGNC:66542
Mus musculus	TRIM46	MGD	MGI:2673000
Macaca mulatta	TRIM46	VGNC	VGNC:79170
Canis familiaris	TRIM46	VGNC	VGNC:47825
Others	TRIM46	NCBI