AKAP1 - A-kinase anchoring protein 1 Gene

Also Known as AKAP; PRKA1; AKAP84; TDRD17; AKAP121; AKAP149; D-AKAP1; PPP1R43; SAKAP84

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8165

About AKAP1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,085,246-57,121,344 (from NCBI)

This gene has 19 transcripts (splice variants) and 229 orthologues. Broad expression in testis (RPKM 41.4), heart (RPKM 27.0) and 24 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]

AKAP1 Products (8)

mRNA	Protein	Name
NM_001242902.1	NP_001229831.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001242903.1	NP_001229832.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370423.1	NP_001357352.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370424.1	NP_001357353.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370425.1	NP_001357354.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370426.1	NP_001357355.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370427.1	NP_001357356.1	A-kinase anchor protein 1, mitochondrial precursor
NM_003488.4	NP_003479.1	A-kinase anchor protein 1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12223483	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IMP IMP: Inferred from mutant phenotype	31522117	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP1 Protein Structure

KH_1

TUDOR

0
200
400
600
800
903 a.a.

Protein Preferred Names	Protein Names
A-kinase anchor protein 1, mitochondrial	A kinase (PRKA) anchor protein 1

AKAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Tag CoIP	33961781
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	TAP	24981860
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Bait CoIP	24083380
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Filter Binding	16642035
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS29476	Akap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00512	AKAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKAP1	VGNC	VGNC:25779
Rattus norvegicus	AKAP1	RGD	RGD:620826
Macaca mulatta	AKAP1	VGNC	VGNC:69763
Felis catus	AKAP1	VGNC	VGNC:59710
Mus musculus	AKAP1	MGD	MGI:104729
Canis familiaris	AKAP1	VGNC	VGNC:37751
Others	AKAP1	NCBI