BRAP - BRCA1 associated protein Gene

Also Known as IMP; BRAP2; RNF52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8315

About BRAP

Cytogenetic location: 12q24.12 Genomic coordinates (GRCh38): 12:111,642,146-111,685,956 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 24.8), bone marrow (RPKM 8.8) and 24 other tissues.

Summary

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and Other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

BRAP Products (1)

mRNA Protein Name
NM_006768.5 NP_006759.3 BRCA1-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
14724641 GOA
enables nuclear localization sequence binding IDA
IDA: Inferred from direct assay
9497340 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9497340 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
14724641 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14724641 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IDA
IDA: Inferred from direct assay
14724641 GOA
acts upstream of or within Ras protein signal transduction IDA
IDA: Inferred from direct assay
14724641 GOA
involved in negative regulation of signal transduction IDA
IDA: Inferred from direct assay
14724641 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
14724641 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9497340 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14724641 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRAP Protein Structure

BRAP2

BRAP2: BRCA1-associated protein 2 (149 - 257)

zf-RING_2

zf-RING_2: Ring finger domain (263 - 304)

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (317 - 376)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
Protein Preferred Names Protein Names

BRCA1-associated protein

  • RING finger protein 52

BRAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BRAP Q7Z569 YJU2 Homo sapiens Q9BW85
Validated Y2H
32296183
Intra
BRAP Q7Z569 HRAS Homo sapiens P01112
CoIP
14724641
Intra
BRAP Q7Z569 BRAP Homo sapiens Q7Z569
CoIP
14724641
Intra
BRAP Q7Z569 BRCA1 Homo sapiens P38398
Pull Down
9497340
Intra
BRAP Q7Z569 PHLPP1 Homo sapiens O60346
Y2H
25820252
Intra
BRAP Q7Z569 HRAS Homo sapiens P01112
Pull Down
14724641
Intra
BRAP Q7Z569 EFHC1 Homo sapiens Q5JVL4
Y2H
25820252
Intra
BRAP Q7Z569 AKAP3 Homo sapiens O75969
Anti Tag CoIP
25820252
Intra
BRAP Q7Z569 KSR1 Homo sapiens Q8IVT5
CoIP
14724641
Intra
BRAP Q7Z569 AKAP3 Homo sapiens O75969
Y2H
25820252
Intra
BRAP Q7Z569 Dnmt1 Mus musculus P13864
Anti Tag CoIP
25820252
Intra
BRAP Q7Z569 BRAP Homo sapiens Q7Z569
Y2H
25820252
Cross: Cross-species interaction Intra: Intraspecies interaction

BRAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P85593 BRAP Antibody (YA5285) WB Human

Related Diseases

Diseases Alias
Astereognosia

  • Somatosensory Agnosia

  • Tactile Agnosia
Melanoma, Uveal

  • Uveal Melanoma

  • Choroidal Melanoma

  • Melanoma Of Uvea

  • Iris Melanoma

  • Malignant Melanoma Of Choroid

  • Malignant Melanoma Of Iris
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01591 BRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18746 Brap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25233 Brap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BRAP RGD RGD:1586551
Bos taurus BRAP VGNC VGNC:26552
Mus musculus BRAP MGD MGI:1919649
Canis familiaris BRAP VGNC VGNC:38515
Felis catus BRAP VGNC VGNC:60163
Macaca mulatta BRAP VGNC VGNC:70278
Others BRAP NCBI