TRIM55 - tripartite motif containing 55 Gene

Also Known as RNF29; muRF2; MURF-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84675

About TRIM55

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,113,351-66,175,485 (from NCBI)

This gene has 5 transcripts (splice variants), 272 orthologues and 80 paralogues. Biased expression in heart (RPKM 14.3), liver (RPKM 6.5) and 2 other tissues.

Summary

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, Myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TRIM55 Products (4)

mRNA	Protein	Name
NM_033058.3	NP_149047.2	tripartite motif-containing protein 55 isoform 2
NM_184085.2	NP_908973.1	tripartite motif-containing protein 55 isoform 1
NM_184086.2	NP_908974.1	tripartite motif-containing protein 55 isoform 3
NM_184087.2	NP_908975.1	tripartite motif-containing protein 55 isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22493164	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22493164	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	37816088	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	37816088	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	37816088	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	37816088	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM55 Protein Structure

zf-C3HC4_2

zf-B_box

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 55	muscle specific ring finger 2

TRIM55 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM55	Q9BYV6	USP13	Homo sapiens	Q92995	Anti Tag CoIP	31391242
Intra	TRIM55	Q9BYV6	USP35	Homo sapiens	Q9P2H5	Anti Tag CoIP	31391242
Intra	TRIM55	Q9BYV6	USP13	Homo sapiens	Q92995	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	AEBP2	Homo sapiens	Q6ZN18-2	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	acbd4	Homo sapiens	EBI-21999915	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	TRIM55	Homo sapiens	Q9BYV6	Y2H Array	22493164
Intra	TRIM55	Q9BYV6	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	znf767-5	Homo sapiens	EBI-22023041	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	SERPINB3	Homo sapiens	P29508	Anti Tag CoIP	33961781
Intra	TRIM55	Q9BYV6	TRIM55	Homo sapiens	Q9BYV6	Anti Tag CoIP	22493164
Intra	TRIM55	Q9BYV6	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	MYLK2	Homo sapiens	Q9H1R3	Anti Tag CoIP	31391242
Intra	TRIM55	Q9BYV6	ypel3-5	Homo sapiens	EBI-22021574	Y2H Prey Pooling	31391242
Intra	TRIM55	Q9BYV6	ACD	Homo sapiens	Q96AP0	Y2H Prey Pooling	31391242

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyaline Body Myopathy	Myosin Storage Myopathy Autosomal Dominant Hyaline Body Myopathy Myopathy, Myosin Storage
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Noonan Syndrome 8	NS8 Noonan Syndrome, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15056	TRIM55 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM55	VGNC	VGNC:78951
Rattus norvegicus	TRIM55	RGD	RGD:1306943
Bos taurus	TRIM55	VGNC	VGNC:36341
Mus musculus	TRIM55	MGD	MGI:3036269
Felis catus	TRIM55	VGNC	VGNC:66545
Canis familiaris	TRIM55	VGNC	VGNC:47827
Others	TRIM55	NCBI