2. Gene
  3. RGS11 - regulator of G protein signaling 11 Gene

RGS11 - regulator of G protein signaling 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RS11

Gene ID: 8786 | Gene type: protein coding

About RGS11

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:268,307-275,944 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 23 paralogues. Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

RGS11 Products(4)

mRNA Protein Name
NM_001286485.2 NP_001273414.1 regulator of G-protein signaling 11 isoform 3
NM_001286486.2 NP_001273415.1 regulator of G-protein signaling 11 isoform 4
NM_003834.3 NP_003825.1 regulator of G-protein signaling 11 isoform 2
NM_183337.3 NP_899180.1 regulator of G-protein signaling 11 isoform 1

RGS11 Protein Structure

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (35 - 105)

G-gamma

G-gamma: GGL domain (224 - 284)

RGS

RGS: Regulator of G protein signaling domain (303 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 11

regulator of G-protein signalling 11

Related Diseases

Diseases Alias
Prolonged Electroretinal Response Suppression

Bradyopsia

PERRS
Bullous Retinoschisis
Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11904 RGS11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS11 MGD MGI:1354739
Macaca mulatta RGS11 VGNC VGNC:76916
Canis familiaris RGS11 VGNC VGNC:45521
Felis catus RGS11 VGNC VGNC:69311
Bos taurus RGS11 VGNC VGNC:33912
Rattus norvegicus RGS11 RGD RGD:3563