RGS11 - regulator of G protein signaling 11 Gene

Also Known as RS11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8786

About RGS11

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:268,307-275,944 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 23 paralogues. Broad expression in brain (RPKM 9.1), fat (RPKM 7.5) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

RGS11 Products (4)

mRNA Protein Name
NM_001286485.2 NP_001273414.1 regulator of G-protein signaling 11 isoform 3
NM_001286486.2 NP_001273415.1 regulator of G-protein signaling 11 isoform 4
NM_003834.3 NP_003825.1 regulator of G-protein signaling 11 isoform 2
NM_183337.3 NP_899180.1 regulator of G-protein signaling 11 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein beta-subunit binding IPI
IPI: Inferred from physical interaction
12606627 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
18468998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS11 Protein Structure

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (35 - 105)

G-gamma

G-gamma: GGL domain (224 - 284)

RGS

RGS: Regulator of G protein signaling domain (303 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 11

  • regulator of G-protein signalling 11

Related Diseases

Diseases Alias
Prolonged Electroretinal Response Suppression

  • Bradyopsia

  • PERRS
Bullous Retinoschisis
Congenital Stationary Night Blindness

  • Night Blindness, Congenital Stationary

  • Congenital Essential Nyctalopia

  • Oguchi Disease

  • Blindness, Night, Stationary, Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11904 RGS11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS11 MGD MGI:1354739
Macaca mulatta RGS11 VGNC VGNC:76916
Canis familiaris RGS11 VGNC VGNC:45521
Felis catus RGS11 VGNC VGNC:69311
Bos taurus RGS11 VGNC VGNC:33912
Rattus norvegicus RGS11 RGD RGD:3563
Others RGS11 NCBI