TAF1C - TATA-box binding protein associated factor, RNA polymerase I subunit C Gene

Homo sapiens

Also known as SL1; TAFI95; TAFI110; MGC:39976

Gene ID: 9013 | Gene type: protein coding

About TAF1C

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,177,855-84,187,057 (from NCBI)

This gene has 23 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in spleen (RPKM 19.0), ovary (RPKM 12.6) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

TAF1C Products(7)

mRNA	Protein	Name
NM_001243156.2	NP_001230085.2	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 3
NM_001243157.2	NP_001230086.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 4
NM_001243158.2	NP_001230087.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 4
NM_001243159.2	NP_001230088.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 5
NM_001243160.2	NP_001230089.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 6
NM_005679.4	NP_005670.4	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1
NM_139353.3	NP_647610.3	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 2

Protein Preferred Names

Protein Names

TATA box-binding protein-associated factor RNA polymerase I subunit C

RNA polymerase I-specific TBP-associated factor 110 kDa

Related Diseases

Diseases

Alias

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14164	TAF1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAF1C	VGNC	VGNC:47079
Macaca mulatta	TAF1C	VGNC	VGNC:78089
Felis catus	TAF1C	VGNC	VGNC:82313
Mus musculus	TAF1C	MGD	MGI:109576
Bos taurus	TAF1C	VGNC	VGNC:35571
Rattus norvegicus	TAF1C	RGD	RGD:1305658

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