SMDT1 - single-pass membrane protein with aspartate rich tail 1 Gene

Also Known as DDDD; EMRE; C22orf32

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91689

About SMDT1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,079,700-42,084,284 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele and 190 orthologues. Ubiquitous expression in ovary (RPKM 28.8), prostate (RPKM 18.9) and 25 other tissues.

Summary

This gene encodes a core regulatory component of a Calcium Channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]

SMDT1 Products (1)

mRNA Protein Name
NM_033318.5 NP_201575.3 essential MCU regulator, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables channel activator activity IDA
IDA: Inferred from direct assay
31080062 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27099988 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
32494073 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
31080062 GOA
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
27099988 GOA
involved in cellular response to calcium ion starvation IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
24231807 GOA
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24231807 GOA
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
31080062 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IPI
IPI: Inferred from physical interaction
32494073 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMDT1 Protein Structure

DDDD

DDDD: Putative mitochondrial precursor protein (31 - 107)

  • 0
  • 100
  • 107 a.a.
Protein Preferred Names Protein Names

essential MCU regulator, mitochondrial

  • UPF0466 protein C22orf32, mitochondrial

SMDT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMDT1 Q9H4I9 MYLK2 Homo sapiens Q9H1R3
Anti Tag CoIP
33961781
Intra
SMDT1 Q9H4I9 MYLK2 Homo sapiens Q9H1R3
Anti Tag CoIP
28514442
Intra
SMDT1 Q9H4I9 MCU Homo sapiens Q8NE86
GMS
32494073
Intra
SMDT1 Q9H4I9 MCU Homo sapiens Q8NE86
Anti Tag CoIP
33961781
Intra
SMDT1 Q9H4I9 MCU Homo sapiens Q8NE86
3D-EM-Single
32494073
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eastern Equine Encephalitis

  • Eee

  • Neuroinvasive Eastern Equine Encephalitis Virus Infection

  • Eastern Equine Encephalomyelitis

  • Encephalomyelitis, Eastern Equine

  • Triple E

  • Eastern Equine Encephalitis Virus Infection

  • Neuroinvasive Eastern Equine Encephalitis Virus Disease

  • Eee - [Eastern Equine Encephalitis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13429 SMDT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21758 Smdt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28276 Smdt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SMDT1 MGD MGI:1916279
Rattus norvegicus SMDT1 RGD RGD:1311310
Macaca mulatta SMDT1 VGNC VGNC:77771
Canis familiaris SMDT1 VGNC VGNC:46553
Bos taurus SMDT1 VGNC VGNC:35009
Felis catus SMDT1 VGNC VGNC:65485