2. Gene
  3. CHMP4C - charged multivesicular body protein 4C Gene

CHMP4C - charged multivesicular body protein 4C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Shax3; SNF7-3; VPS32C

Gene ID: 92421 | Gene type: protein coding

About CHMP4C

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,732,448-81,759,515 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 19.0), small intestine (RPKM 14.8) and 19 other tissues.

Summary

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP4C Products(1)

mRNA Protein Name
NM_152284.4 NP_689497.1 charged multivesicular body protein 4c

CHMP4C Protein Structure

Snf7

Snf7: Snf7 (24 - 192)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

charged multivesicular body protein 4c

SNF7 homolog associated with Alix 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02645 CHMP4C Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CHMP4C VGNC VGNC:71143
Canis familiaris CHMP4C VGNC VGNC:39224
Bos taurus CHMP4C VGNC VGNC:27303
Felis catus CHMP4C VGNC VGNC:60864
Rattus norvegicus CHMP4C RGD RGD:1564543
Mus musculus CHMP4C MGD MGI:1913621