2. Academic Validation
  3. 4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain

4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain

  • J Antibiot (Tokyo). 2000 Sep;53(9):895-902. doi: 10.7164/antibiotics.53.895.
L M Hernández 1,  J A Blanco,  J P Baz,  J L Puentes,  F R Millán,  F E Vázquez,  R I Fernández-Chimeno,  D G Grávalos
Affiliations

Affiliation

  • 1 Instituto Biomar S.A., Pol. Ind., León, Spain.
PMID: 11099222 DOI: 10.7164/antibiotics.53.895
Abstract

Two new indolocarbazole Alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.

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