2. Academic Validation
  3. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea

Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea

  • Chem Pharm Bull (Tokyo). 2003 Apr;51(4):425-6. doi: 10.1248/cpb.51.425.
Yao-Haur Kuo 1,  Yu-Jen Kuo,  Ang-Su Yu,  Ming-Der Wu,  Chi-Wi Ong,  Li-Ming Yang Kuo,  Jo-Ti Huang,  Chieh-Fu Chen,  Shyh-Yuan Li
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C. [email protected]
PMID: 12672998 DOI: 10.1248/cpb.51.425
Abstract

Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED(50)=0.02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively).

Figures
Products