Synthesis of 15R-PGD2: a potential DP2 receptor agonist

  • Bioorg Med Chem Lett. 2005 Apr 1;15(7):1873-6. doi: 10.1016/j.bmcl.2005.02.011.
Seongjin Kim  1 ,  Sophie Bellone ,  Kirk M Maxey ,  William S Powell ,  Gue-Jae Lee ,  Joshua Rokach
Affiliations
  • 1. Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 W. University Blvd., Melbourne, FL 32901, USA.
PMID: 15780624 DOI: 10.1016/j.bmcl.2005.02.011
Abstract

The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.

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