2. Academic Validation
  3. The essential roles of TGFB1 in reproduction

The essential roles of TGFB1 in reproduction

  • Cytokine Growth Factor Rev. 2009 Jun;20(3):233-9. doi: 10.1016/j.cytogfr.2009.05.003.
Wendy V Ingman 1,  Sarah A Robertson
Affiliations

Affiliation

  • 1 Discipline Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia. [email protected]
PMID: 19497778 DOI: 10.1016/j.cytogfr.2009.05.003
Abstract

Transforming growth factor beta 1 (TGFB1) is implicated as a key regulator of the development and cyclic remodelling characteristic of reproductive tissues. The physiological significance of TGFB1 in reproductive biology and fertility has been extensively examined in Tgfb1 null mutant mice. Genetic deficiency in TGFB1 causes perturbed functioning of the hypothalamic-pituitary-gonadal axis, inhibiting luteinising hormone (LH) synthesis and leading to downstream effects on testosterone production in males and estrous cycle abnormalities in females. Oocyte developmental incompetence, accompanied by early embryo arrest as well as altered pubertal mammary gland morphogenesis are observed. In addition to LH and testosterone deficiency, male Tgfb1 null mice demonstrate complete inability to mate with females, associated with failure to initiate and/or sustain successful penile intromission or ejaculation. These studies demonstrate the profound significance of TGFB1 in male and female reproductive physiology, and provide a foundation for exploring the significance of this cytokine in human infertility and sexual dysfunction.

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