2. Academic Validation
  3. Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction

  • Bioorg Med Chem Lett. 2011 Apr 1;21(7):2075-8. doi: 10.1016/j.bmcl.2011.02.003.
Ki Hyun Kim 1,  Min Ah Kim,  Eunjung Moon,  Sun Yeou Kim,  Sang Zin Choi,  Mi Won Son,  Kang Ro Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, Gyeonggi-do 440-746, Republic of Korea.
PMID: 21353549 DOI: 10.1016/j.bmcl.2011.02.003
Abstract

The rhizome of Dioscorea japonica is a food and medicinal source known as 'San Yak' in Korea. Two new furostanol saponins, coreajaponins A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of D. japonica. Their structures were determined by spectroscopic methods, including 1D and 2D NMR techniques, HRMS, and chemical methods. Nerve growth factor (NGF), a crucial factor for neuronal survival and differentiation, can potentially improve neurodegenerative diseases and diabetic polyneuropathy. We evaluated the effects of isolates (1-12) on NGF induction in a C6 rat glioma cell line. Coreajaponin B (2) upregulated NGF content without significant cell toxicity, as did 6, 8, 9, and 11.

Figures
Products