2. Academic Validation
  3. A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

  • Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13. doi: 10.1002/anie.201206691.
Jungwoon Lee 1,  Yan Xia,  Mi-Young Son,  Guanghai Jin,  Binna Seol,  Min-Jeong Kim,  Myung Jin Son,  Misol Do,  Minho Lee,  Dongsup Kim,  Kyeong Lee,  Yee Sook Cho
Affiliations

Affiliation

  • 1 Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, S. Korea.
PMID: 23125037 DOI: 10.1002/anie.201206691
Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA Methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Figures
Products