1. Academic Validation
  2. Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458

Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458

  • Mar Biotechnol (NY). 2015 Feb;17(1):110-9. doi: 10.1007/s10126-014-9599-3.
Bin Wu 1 Birgit Ohlendorf Vanessa Oesker Jutta Wiese Susann Malien Rolf Schmaljohann Johannes F Imhoff
Affiliations

Affiliation

  • 1 Wirkstoff-Zentrum am GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel, Kiel, 24105, Germany.
Abstract

Two new oxaphenalenone dimers, talaromycesone A (1) and talaromycesone B (2), and a new isopentenyl xanthenone, talaroxanthenone (3), together with six known diphenyl ether derivatives, e.g., Δ(1',3'),-1'-dehydroxypenicillide (4), 1',2'-dehydropenicillide (5), vermixocin A (6), vermixocin B (7), 3'-methoxy-1'2'-dehydropenicillide (8), and AS-186c (9), were isolated from the culture broth and mycelia of a marine fungus Talaromyces sp. strain LF458. Compound 2 represents the first example of 1-nor oxaphenalenone dimer carbon skeleton. All isolated compounds were subjected to bioactivity assays. Compounds 1, 2, and 9 exhibited potent Antibacterial activities with IC50 3.70, 17.36, and 1.34 μM, respectively, against human pathogenic Staphylococcus strains. Compounds 1, 3, and 9 displayed potent acetylcholinesterase inhibitory activities with IC50 7.49, 1.61, and 2.60 μM, respectively. Interestingly, phosphodiesterase PDE-4B2 was inhibited by compounds 3 (IC50 7.25 μM) and 9 (IC50 2.63 μM).

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