Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis

Background/aims: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice.

Methods: A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total Cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups.

Results: The total Cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although Cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052).

Conclusions: Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total Cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.

Cholesterol; Cholinesterase; Chronic pancreatitis; Diabetes mellitus; Pancreatic exocrine insufficiency.