2. Academic Validation
  3. Two new triterpenoids from Gypsophila oldhamiana

Two new triterpenoids from Gypsophila oldhamiana

  • Nat Prod Res. 2016;30(9):1068-74. doi: 10.1080/14786419.2015.1107060.
Long-Xiao Xie 1 2 3,  Hao-Chao Zhang 1 2 3,  Hai-Yang Wang 1 3,  Yan Wang 1 3,  Feng-Ling Wang 1 3,  Jing-Yong Sun 1 3
Affiliations

Affiliations

  • 1 a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan , P.R. China.
  • 2 b School of Medicine and Life Sciences, Shandong Academy of Medical Sciences , University of Jinan , Jinan , P.R. China.
  • 3 c Key Laboratory of Rare and Uncommon Diseases of Shandong Province , Shandong Academy of Medical Sciences , Jinan , P.R. China.
PMID: 26539898 DOI: 10.1080/14786419.2015.1107060
Abstract

Two new triterpenoids (1-2) were isolated and elucidated from the roots of Gypsophila oldhamiana, together with four known triterpenoids (3-6). Their structures were identified to be 3β-hydroxyolean-13(18)-ene-23, 28-dioic acid (1), 3β, 12α-dihydroxy-23-carboxyolean-28, 13β-olide (2), 3β, 16α-dihydroxy-23-oxoolean-13(18)-en-28-oic acid (3), gypsogenin (4), quillaic acid (5) and gypsogenic acid (6) by spectral methods. All compounds were tested for their cytotoxicities against human tumour cell lines (lung Cancer H460 and gastric Cancer SGC-7901) and for their antiangiogenic effects using a zebra fish model. All compounds showed interesting antiangiogenic activities and the significant cytotoxicities against H460.

Keywords

Gypsophila oldhamiana; antiangiogenic effect; cytotoxic activity; triterpenoid.

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