2. Academic Validation
  3. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

  • Toxicon. 2017 Feb;126:47-50. doi: 10.1016/j.toxicon.2016.12.012.
Johan Lundqvist 1,  Heidi Pekar 2,  Agneta Oskarsson 3
Affiliations

Affiliations

  • 1 Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, SE-750 07 Uppsala, Sweden. Electronic address: [email protected].
  • 2 National Food Agency, Science Department, Chemistry Division, P.O. Box 622, 75126 Uppsala, Sweden.
  • 3 Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, P.O. Box 7028, SE-750 07 Uppsala, Sweden.
PMID: 28017693 DOI: 10.1016/j.toxicon.2016.12.012
Abstract

Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and -RR at 10 μM, by microcystin-LY at 3 μM, by [D-Asp3]-LR and by microcystin-LR at 1 μM. Our results lend support to the suggestion that microcystins may induce oxidative stress response.

Keywords

Microcystins; Nrf2; Oxidative stress.

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