2. Academic Validation
  3. Liposome-aided metabolic engineering of tumor surface immunogenicity

Liposome-aided metabolic engineering of tumor surface immunogenicity

  • Bioorg Med Chem Lett. 2018 Aug 1;28(14):2550-2554. doi: 10.1016/j.bmcl.2018.05.037.
Nianfeng Zheng 1,  Siyu Wang 1,  Xinhui Su 2,  Shoufa Han 3
Affiliations

Affiliations

  • 1 State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China.
  • 2 Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen 361004, China. Electronic address: [email protected].
  • 3 State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China. Electronic address: [email protected].
PMID: 29941189 DOI: 10.1016/j.bmcl.2018.05.037
Abstract

Approaches to increase tumor immunogenicity are of therapeutic potentials. We herein reported the use of liposomes for covalent incorporation of neoantigen on tumor surfaces with DNP-conjugated sialic acid (DNPSia). Relative to free DNPSia, sugar-encapsulated biotinylated liposomes (DNPSia@LP@biotin) enables effective cell surface expression of DNPSia on biotin receptor (BR)-expressing cells over BR-free cells in vitro, and on tumor cell surfaces with high tumor-to-normal tissue contrast in a mice model. These findings suggest the potentials of targetable liposomes for modulating tumor surface immunity via metabolic oligosaccharide engineering.

Keywords

Cell surface engineering; Immunomodulation; Sialic acid; Targetable liposome; Tumor.

Figures
Products