2. Academic Validation
  3. Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors

Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors

  • J Med Chem. 2019 Apr 25;62(8):4110-4119. doi: 10.1021/acs.jmedchem.9b00142.
Kalanidhi Palanichamy 1 2,  Anjali Joshi 3,  Tugba Mehmetoglu-Gurbuz 3,  M Fernando Bravo 1 2 4,  Milan A Shlain 1 2,  Frank Schiro 1 2,  Yasir Naeem 1 2,  Himanshu Garg 3,  Adam B Braunschweig 1 2 4 5
Affiliations

Affiliations

  • 1 Nanoscience Initiative, Advanced Science Research Center at the Graduate Center of the City University of New York , 85 St. Nicholas Terrace , New York , New York 10031 , United States.
  • 2 Department of Chemistry and Biochemistry , Hunter College , 695 Park Avenue , New York , New York 10065 , United States.
  • 3 Center of Emphasis in Infectious Diseases, Department of Biomedical Sciences , Texas Tech University Health Sciences Center in El Paso , 5001 El Paso Drive , El Paso , Texas 79905 , United States.
  • 4 The Ph.D. Program in Chemistry, The Graduate Center of the City University of New York , 365 Fifth Avenue , New York , New York 10016 , United States.
  • 5 The Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York , 365 Fifth Avenue , New York , New York 10016 , United States.
PMID: 30925051 DOI: 10.1021/acs.jmedchem.9b00142
Abstract

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a global health concern because of its association with severe neurological disorders. Currently, there are no Antiviral therapies that have been specifically approved to treat ZIKV, and there is an urgent need to develop effective anti-ZIKV agents. Here, we report anti-ZIKV activity of 16 synthetic carbohydrate receptors (SCRs) that inhibit ZIKV Infection in Vero and HeLa cells. Using a ZIKV reporter virus particle-based Infection assay, our data demonstrates these SCRs are highly potent with IC50s as low as 0.16 μM and negligible toxicity at several-fold higher concentrations. Time-of-addition studies showed that these SCRs inhibit the early stages of the virus Infection, which is consistent with the proposed mode of action, where the SCRs likely inhibit binding between the virus and cell-surface glycans, thereby preventing viral entry into the cells and, as such, this study demonstrates a potential new strategy against ZIKV.

Figures
Products