2. Academic Validation
  3. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects

Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects

  • J Agric Food Chem. 2019 May 8;67(18):5147-5158. doi: 10.1021/acs.jafc.9b01195.
Yan-Li Wu 1,  Fei Han 1,  Shan-Shan Luan 2,  Rui Ai 1,  Peng Zhang 1,  Hua Li 1 2,  Li-Xia Chen 1
Affiliations

Affiliations

  • 1 Wuya College of Innovation, School of Pharmacy, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • 2 School of Pharmacy, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430030 , China.
PMID: 30995041 DOI: 10.1021/acs.jafc.9b01195
Abstract

Ganoderma lucidum, as food, tea, dietary supplement, and medicine, is widely used in China and Eastern Asian countries. In order to discover its anti-inflammatory constituents and provide some references for the usage of G. lucidum and G. sinense, two official species in China, the fruiting bodies of G. lucidum were studied, leading to the isolation of six new triterpenoids (1-6) and 27 known analogues (7-33). Compound 4 exhibited the most potent inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophage cells. The production of IL-6 and IL-1β, as well as the expression of iNOS, COX-2, and NF-κB were dose-dependently reduced by 4. The phosphorylations of IκBα and IKKβ in LPS-induced macrophage cells were blocked by 4. Therefore, 4 could be used as a potential anti-inflammatory candidate and the total triterpenoids might be developed as value-added functional food for the prevention of inflammation. In combination of previous studies, it should be cautious for the interchangeable usage of G. lucidum and G. sinense.

Keywords

Ganoderma lucidum; anti-inflammation; triterpenoids.

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