2. Academic Validation
  3. c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

  • Aging (Albany NY). 2020 Apr 27;12(8):7397-7410. doi: 10.18632/aging.103086.
Liang Li 1,  Chenju Yi 1,  WenJie Xia 2,  Bihui Huang 1,  Shichao Chen 1,  Junyan Zhong 1,  Xiaoyi Fang 1,  Liuming Yang 3,  Hongwu Xin 3,  Shiying Silvia Zheng 4 5,  Beng H Chong 4 5,  Yingyun Fu 6,  Chun Chen 1,  Mo Yang 1 3
Affiliations

Affiliations

  • 1 The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • 2 Guangzhou Blood Center, Guangzhou, Guangdong, China.
  • 3 Lianjiang People's Hospital, Lianjiang, Guangdong, China.
  • 4 St. George and Sutherland Clinical School, University of New South Wales, Kogarah, NSW, Australia.
  • 5 Department of Haematology, St. George Hospital, Kogarah, NSW, Australia.
  • 6 Department of Pulmonary and Critical Care Medicine, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
PMID: 32341206 DOI: 10.18632/aging.103086
Abstract

Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central nervous system (CNS) and their roles after a neural insult. Our results demonstrate that both TPO and c-Mpl are expressed in the neurons of the human CNS. TPO was also detected in human cerebrospinal fluid. TPO was found to be neuroprotective in hypoxic-ischemic neonatal rat brain models. In these rat models, treatment with TPO reduced brain damage and improved sensorimotor functions. In addition, TPO promoted C17.2 cell proliferation through activation of the PI3K/Akt signaling pathway. Via the Bcl-2/Bax signaling pathway, TPO exerted an antiapoptotic effect by suppressing mitochondrial membrane potentials. Taken together, our results indicate that TPO is neuroprotective in the CNS.

Keywords

C-Mpl; CNS; antiapoptosis; brain damage; thrombopoietin.

Figures
Products