1H-nmr analysis of herbimycins and dihydro-herbimycins

  • J Nat Prod. 1988 Nov-Dec;51(6):1161-5. doi: 10.1021/np50060a018.
L Z Lin  1 ,  G Blaskó ,  G A Cordell
Affiliations
  • 1. Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
PMID: 3236008 DOI: 10.1021/np50060a018
Abstract

Herbimycin A [1] and herbimycin C [3] and their dihydro-derivatives 5 and 6, respectively, have been obtained from the cell broth of Streptomyces hygroscopicus, and the assignment of their 1H-nmr has been completed. Strong cytotoxic activity of Antibiotics 1, 3, 5, and 6 against the P-388 and KB lymphocytic leukemia test systems has been demonstrated.

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