2. Academic Validation
  3. Neuraminidase Inhibitors from the Roots of Caragana sinica

Neuraminidase Inhibitors from the Roots of Caragana sinica

  • Chem Biodivers. 2020 Nov;17(11):e2000470. doi: 10.1002/cbdv.202000470.
SeonJu Park 1,  Nanyoung Kim 2,  Nguyen Xuan Nhiem 3 4,  Hee Jae Kwak 5,  Hyun Wook Yang 5,  Seung Hyun Kim 5
Affiliations

Affiliations

  • 1 Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon, 24341, Republic of, Korea.
  • 2 National Institute of Food and Drug Safety Evaluation Herbal Medicinal Products Division, Ministry of Food and Drug Safety, Chungcheongbuk-do, 28159, Republic of, Korea.
  • 3 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, 10072, Vietnam.
  • 4 Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
  • 5 College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, Republic of, Korea.
PMID: 32996697 DOI: 10.1002/cbdv.202000470
Abstract

Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1 H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.

Keywords

Caragana sinica; ECD calculation; neuraminidase; oligostilbenes.

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