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  3. Wistin

Wistin 

Cat. No.: HY-N9333
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Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist.

For research use only. We do not sell to patients.

Wistin Chemical Structure

Wistin Chemical Structure

CAS No. : 19046-26-5

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Description

Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist[1][2].

In Vitro

Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2].
Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2].
Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2].
Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2].
Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: Mouse hepatocytes.
Concentration: 1 or 10 μg/mL.
Incubation Time: 48 h.
Result: Significantly increased PPARα mRNA levels in a dose-dependent manner.
Molecular Weight

460.43

Formula

C₂₃H₂₄O₁₀

CAS No.
SMILES

O=C1C2=CC(OC)=C(O[[email protected]@H]3O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]3O)O)O)CO)C=C2OC=C1C4=CC=C(C=C4)OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

WistinPPARPeroxisome proliferator-activated receptors3T3-L1adipocyteCPT1aACOACSInhibitorinhibitorinhibit

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Wistin
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HY-N9333
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