1. Academic Validation
  2. Absorption, Distribution, Metabolism, and Excretion of a New Herbicide, Epyrifenacil, in Rats

Absorption, Distribution, Metabolism, and Excretion of a New Herbicide, Epyrifenacil, in Rats

  • J Agric Food Chem. 2021 Nov 10;69(44):13190-13199. doi: 10.1021/acs.jafc.1c04167.
Kengo Sakurai 1 Jun Abe 1 Kota Hirasawa 1 Hayato Takeuchi 1 Sachiko Kitamoto 1
Affiliations

Affiliation

  • 1 Environmental Health Science Laboratory, Sumitomo Chemical Company, Limited, 1-98, Kasugade-naka 3-chome, Konohana-ku, Osaka 554-8558, Japan.
Abstract

The metabolic fate of a newly developed herbicide, epyrifenacil, (ethyl[(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, S-3100), in rats was determined using 14C-labeled epyrifenacil. When it was administered orally to rats at 1 mg/kg, around 73-74% of the dose was absorbed, metabolized, and mainly excreted into feces within 48 h. The elimination of radioactivity in plasma and tissues was rapid, suggesting that exposure of epyrifenacil and metabolites is small. Metabolite analysis revealed that epyrifenacil was rapidly ester-cleaved to M1 and then mainly excreted into bile or further metabolized. No parent was detected in plasma, tissues, and urine. Remarkably, M1 was mainly distributed in the liver (at a concentration of 70-112 times higher than in plasma at a low dose). Furthermore, a significant sex-related difference was observed in urinary excretion of M1. Considering the above observations with those in the literature, the organic anion-transporting polypeptide (OATP) likely plays a role on the active transport of M1 in the liver and kidney.

Keywords

S-3100; epyrifenacil; organic anion-transporting polypeptide; rat; transporter.

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