2. Academic Validation
  3. Centipede Venom: A Potential Source of Ion Channel Modulators

Centipede Venom: A Potential Source of Ion Channel Modulators

  • Int J Mol Sci. 2022 Jun 26;23(13):7105. doi: 10.3390/ijms23137105.
Anna Luo 1 2 3,  Aili Wang 1,  Peter Muiruri Kamau 2 3,  Ren Lai 1 2 3,  Lei Luo 2
Affiliations

Affiliations

  • 1 Center for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
  • 2 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming 650107, China.
  • 3 University of Chinese Academy of Sciences, Beijing 100049, China.
PMID: 35806107 DOI: 10.3390/ijms23137105
Abstract

Centipedes are one of the most ancient and successful living venomous Animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including NaV, KV, CaV, and TRP families, are the major targets of peptide neurotoxins. Insight into the mechanism of neurotoxins acting on ion channels contributes to our understanding of the function of both channels and centipede venoms. Meanwhile, the novel structure and selective activities give them the enormous potential to be modified and exploited as research tools and biological drugs. Here, we review the centipede venom Peptides that act on ion channels.

Keywords

RhTx; SsTx; centipede; ion channel; toxin.

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