2. Academic Validation
  3. Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis-apoptosis anticancer therapy

Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis-apoptosis anticancer therapy

  • J Nanobiotechnology. 2023 Sep 2;21(1):311. doi: 10.1186/s12951-023-02059-y.
Jianxin Wang 1,  Yinzhu Chu 1,  Zhiyu Zhao 1,  Cong Zhang 1,  Qi Chen 1,  Haitao Ran 2,  Yang Cao 3,  Changjun Wu 4
Affiliations

Affiliations

  • 1 Department of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
  • 2 Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, State Key Laboratory of Ultrasound in Medicine and Engineering,, Chongqing Medical University, Chongqing, 400010, China.
  • 3 Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, State Key Laboratory of Ultrasound in Medicine and Engineering,, Chongqing Medical University, Chongqing, 400010, China. [email protected].
  • 4 Department of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. [email protected].
PMID: 37660123 DOI: 10.1186/s12951-023-02059-y
Abstract

Graphdiyne has excellent potential due to its enzymatic properties. Metal-free sulfur-doped Graphdiyne (S-GDY) has piezoelectric characteristics, and ultrasonic excitation of S-GDY enhances peroxidase activity. It can turn hydrogen peroxide into toxic hydroxyl radicals and induce Apoptosis in 4T1 cells. More importantly, the ultrasound (US) enhanced nanozyme induced 4T1 cell Ferroptosis by promoting an imbalanced redox reaction due to glutathione depletion and Glutathione Peroxidase 4 inactivation. S-GDY exhibited enhanced nanozyme activity in vitro and in vivo that may directly trigger apoptosis-ferroptosis for effective tumor therapy. Altogether, this study was expected to provide new insights into the design of piezoelectric catalytic nanozyme and expand their application in the catalytic therapy of tumors.

Keywords

Ferroptosis; Graphdiyne; Nanozymes; Piezoelectric catalytic therapy; Ultrasound.

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