2. Academic Validation
  3. MS-444, a new inhibitor of myosin light chain kinase from Micromonospora sp. KY7123

MS-444, a new inhibitor of myosin light chain kinase from Micromonospora sp. KY7123

  • J Antibiot (Tokyo). 1995 Sep;48(9):948-51. doi: 10.7164/antibiotics.48.948.
S Nakanishi 1,  S Chiba,  H Yano,  I Kawamoto,  Y Matsuda
Affiliations

Affiliation

  • 1 Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
PMID: 7592060 DOI: 10.7164/antibiotics.48.948
Abstract

A novel compound MS-444 was isolated from the culture broth of a Bacterial strain KY7123. The strain was identified as Micromonospora sp. from its morphological and cultural characteristics. The compound inhibited the activity of purified smooth muscle Myosin light chain kinase with an IC50 value of 10 microM. The production, isolation, physico-chemical properties and biological activities of MS-444 were described in this paper.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-100685
    99.42%, MLCK Inhibitor