2. Academic Validation
  3. Omega-conotoxin-MVIID blocks an omega-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells

Omega-conotoxin-MVIID blocks an omega-conotoxin-GVIA-sensitive, high-threshold Ca2+ current in fish retinal ganglion cells

  • Neuropharmacology. 1996 May;35(5):633-6. doi: 10.1016/0028-3908(96)84634-x.
T Tabata 1,  B M Olivera,  A T Ishida
Affiliations

Affiliation

  • 1 Section of Neurobiology, Physiology, and Behavior, University of California, Davis 95616, USA.
PMID: 8887972 DOI: 10.1016/0028-3908(96)84634-x
Abstract

Reduction of Ca2+ current amplitude by the Conus peptide omega-conotoxin-MVIID (omega-CTx-MVIID) was measured in voltage-clamped, goldfish retinal ganglion cells. Effects of depolarizing shifts in holding potential, and sequential applications of omega-CTx-MVIID, omega-CTx-GVIA, and BAY-K-8644, together with effects of Ni2+ and omega-Aga-IIIA, indicated that omega-CTx-MVIID may target Ca2+ channels differing from those termed T, L, N, P < Q and R.

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