2. Academic Validation
  3. Inhibition of the reuptake of serotonin by tryptoline

Inhibition of the reuptake of serotonin by tryptoline

  • Naunyn Schmiedebergs Arch Pharmacol. 1976;292(1):93-5. doi: 10.1007/BF00506495.
H Rommelspacher,  P Bade,  H Coper,  G Kossmehl
PMID: 934360 DOI: 10.1007/BF00506495
Abstract

Tryptoline, a metabolite of tryptamine, competitively inhibits serotonin accumulation in nuclei-free homogenate of rat "forebrains". After intraventricular injection the drug elicits an increase of serotonin levels in the same part of the brain whereas the Monoamine Oxidase activity is not altered.

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