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  3. MS645

MS645 

Cat. No.: HY-125232 Purity: 98.03%
Handling Instructions

MS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells.

For research use only. We do not sell to patients.

MS645 Chemical Structure

MS645 Chemical Structure

CAS No. : 2250091-96-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 237 In-stock
Estimated Time of Arrival: December 31
5 mg USD 127 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
25 mg USD 510 In-stock
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50 mg USD 940 In-stock
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100 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells[1].

IC50 & Target[1]

BRD4(BD1BD2)

18.4 nM (Ki)

In Vitro

MS645 has cell growth inhibitory effects on noncancer cell lines of mouse macrophage RAW cells and nontumorigenic breast epithelial MCF10A with IC50s of 4.1 nM, 6.8 nM, 7.9 nM for triple-negative breast cancer (TNBC) cell lines HS5878T, BT549, and MCF 10A[1].
MS645 (15, 30, 60 nM) results in a dramatic reduction of c-Myc expression and an increase of p21, a tumor suppressor and cell-cycle inhibitor in HCC1806 cells[1].

Molecular Weight

938.04

Formula

C₄₈H₅₄Cl₂N₁₀O₂S₂

CAS No.

2250091-96-2

SMILES

O=C(NCCCCCCCCCCNC(C[[email protected]]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)C[[email protected]]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (213.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0661 mL 5.3303 mL 10.6605 mL
5 mM 0.2132 mL 1.0661 mL 2.1321 mL
10 mM 0.1066 mL 0.5330 mL 1.0661 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (5.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MS645MS 645MS-645Epigenetic Reader DomainInhibitorinhibitorinhibit

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MS645
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