1. Metabolic Enzyme/Protease
  2. Pyruvate Kinase
  3. PKR activator 2

PKR activator 2 

Cat. No.: HY-135884
Handling Instructions

PKR activator 2 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385.

For research use only. We do not sell to patients.

PKR activator 2 Chemical Structure

PKR activator 2 Chemical Structure

CAS No. : 2283422-04-6

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Description

PKR activator 2 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385[1].

IC50 & Target

Pyruvate kinase-R (PKR)[1]

In Vitro

PKR activator 2 (compound 385) activates wild type PKR, PKR K410E or PKR 510Q with AC50 values <0.3 µΜ[1].
Pyruvate kinase deficiency (PKD) is a disease of red blood cells caused by a deficiency of pyruvate kinase R (PKR) enzyme as a result of autosomal recessive mutations of the PKLR gene. PKR activators can be beneficial to treat disorders and conditions such as but not limited to PKD, thalassemia, hereditary elliptocytosis, anemia (e.g. , congenital anemias (e.g., enzymopathies), hemolytic anemia (e.g. hereditary and/or congenital hemolytic anemia, acquired hemolytic anemia, chronic hemolytic anemia caused by phosphoglycerate kinase deficiency, anemia of chronic diseases, non-spherocytic hemolytic anemia or hereditary spherocytosis)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.44

Formula

C18H16N8OS

CAS No.
SMILES

O=C1C(N(C)C2=C3SC(CC4=NNC=C4)=N2)=C3C=NN1CC5=NC(N)=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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PKR activator 2
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HY-135884
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