2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Growth Differentiation Factor
  6. Growth Differentiation Factor 9 (GDF-9)

Growth Differentiation Factor 9 (GDF-9)

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Growth Differentiation Factor 9 (GDF-9)

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GDF-9 belongs to TGFβ family. GDF-9 regulates ovarian function, and plays a vital role for fertility. GDF-9 is mainly expressed in the oocytes of ovarian follicles, and some testicular and hypophyseal expression has been detected. GDF-9 is normally secreted by oocytes, and promotes the growth, development, and survival of human ovarian follicles. GDF-9 binds to TGF-β type II receptors (ALK5 and to BMPRII) and exhibits its biological effect[1][2]. Specifically, the activated type II receptor phosphorylates Smad 2/3 proteins. pSmad 2/3 interacts with Smad4, and finally regulates the expression of target genes. GDF-9 also stimulates the expression of the FSHR, protects cells against atresia, promotes cell proliferation, reduces LHR expression and affects the steroidogenesis of granulosa cells[3]. Human GDF-9 shares about 74% aa sequence identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72425
    GDF-9 Protein, Human (GST)

    GDF9; Growth/differentiation factor 9; GDF-9

    		Human E. coli
    The GDF-9 protein is critical for ovarian folliculogenesis, promoting primordial follicle development and stimulating granulosa cell proliferation. It induces cell cycle transition, upregulates CCND1 and CCNE1 expression, and phosphorylates RB1. GDF-9 Protein, Human (GST) is the recombinant human-derived GDF-9 protein, expressed by E. coli , with N-GST labeled tag. The total length of GDF-9 Protein, Human (GST) is 135 a.a., with molecular weight of ~42.5 kDa.
Cat. No. Product Name Effect Purity