1. Recombinant Proteins
  2. Angiogenin Protein, Human

Angiogenin Protein, Human

Cat. No.: HY-P7503
Handling Instructions

Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.

For research use only. We do not sell to patients.

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuAngiogenin; ANG; RNASE5; Angiogenin
Species

Human

Source

E. coli

Accession

P03950 (Q25-P147)

Gene ID

283

Molecular Weight

Approximately 14.0 kDa

AA Sequence

QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP

Biological Activity
Data is not available.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PBS, 150 mM NaCl, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Angiogenin (Ang) is one of the members of the pancreatic ribonuclease (RNase) superfamily that have unusual biological properties. The amino acid sequence of angiogenin revealed that it was homologous to RNase A. It shares 33% sequence identity with the bovine enzyme, including counterparts to the two histidines and one lysine that constitute the catalytic active site. It belongs to the pancreatic RNase superfamily of proteins and is specifically endocytosed by endothelial cells and transported to the nucleus, where it accumulates in the nucleolus.

Documentation
References
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Product Name:
Angiogenin Protein, Human
Cat. No.:
HY-P7503
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