Angiogenin Protein, Human
Based on 5 publication(s) in Google Scholar
Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.
Background
Angiogenin (Ang) is one of the members of the pancreatic ribonuclease (RNase) superfamily that have unusual biological properties. The amino acid sequence of angiogenin revealed that it was homologous to RNase A. It shares 33% sequence identity with the bovine enzyme, including counterparts to the two histidines and one lysine that constitute the catalytic active site. It belongs to the pancreatic RNase superfamily of proteins and is specifically endocytosed by endothelial cells and transported to the nucleus, where it accumulates in the nucleolus.
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5'tiRNAGly-GCC production. [Abstract]2026 Feb 21;17(1):240. PMID: 41723159 -
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Biol Reprod
Angiogenin-driven rRNA transcriptional activation regulates endometrial receptivity through epithelial remodeling†. [Abstract]2026 Jul 15;115(1):75-88. PMID: 42033304 -
Animals (Basel)
2025 Jul 8;15(14):2002. PMID: 40723465 -
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P03950 (Q25-P147)
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Molecular Construction
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N-term
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Angiogenin (Q25-P147)
Accession # P03950 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
ANG; Angiogenin, Ribonuclease, RNase A Family, 5; Angiogenin; Ribonuclease A Family Member 5; RNASE5; RNase 5; Ribonuclease 5; Epididymis Luminal Protein 168; HEL168; Ribonuclease A A1; RAA1; RNASE4; Homo Sapiens Epididymis Luminal Protein 168; ALS9
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AA Sequence
QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP
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Predicted Molecular Mass
14.3 kDa
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Molecular Weight
Approximately 14 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Angiogenin.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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