1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. Angiogenin Protein, Human

Angiogenin Protein, Human

Cat. No.: HY-P7503
COA Handling Instructions

Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μg $125 In-stock
50 μg $320 In-stock
100 μg   Get quote  
250 μg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

  • References

Description

Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.

Background

Angiogenin (Ang) is one of the members of the pancreatic ribonuclease (RNase) superfamily that have unusual biological properties. The amino acid sequence of angiogenin revealed that it was homologous to RNase A. It shares 33% sequence identity with the bovine enzyme, including counterparts to the two histidines and one lysine that constitute the catalytic active site. It belongs to the pancreatic RNase superfamily of proteins and is specifically endocytosed by endothelial cells and transported to the nucleus, where it accumulates in the nucleolus.

Biological Activity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Species

Human

Source

E. coli

Tag

Tag Free

Accession

P03950 (Q25-P147)

Gene ID

283  [NCBI]

Synonyms
rHuAngiogenin; ANG; RNASE5; Angiogenin
AA Sequence

QDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP

Molecular Weight

Approximately 14.0 kDa

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PBS, 150 mM NaCl, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
References

Angiogenin Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Angiogenin Protein, Human
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HY-P7503
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