ANG - angiogenin Gene

Also Known as ALS9; RAA1; HEL168; RNASE4; RNASE5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283

About ANG

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,177-20,694,186 (from NCBI)

This gene has 3 transcripts (splice variants), 98 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

ANG Products (6)

mRNA	Protein	Name
NM_001097577.3	NP_001091046.1	angiogenin precursor
NM_001145.4	NP_001136.1	angiogenin precursor
NM_001385271.1	NP_001372200.1	angiogenin precursor
NM_001385272.1	NP_001372201.1	angiogenin precursor
NM_001385273.1	NP_001372202.1	angiogenin precursor
NM_001385274.1	NP_001372203.1	angiogenin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	2424496	GOA
enables actin binding	IDA IDA: Inferred from direct assay	7679494	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	9245697	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	10103013	GOA
enables peptide binding	IDA IDA: Inferred from direct assay	11782452	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2742853	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25372031	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	38718836	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9122172	GOA
enables tRNA-specific ribonuclease activity	IDA IDA: Inferred from direct assay	19332886	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	8448182	GOA
involved in angiogenesis	IDA IDA: Inferred from direct assay	3470787	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	2479414	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12548285	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	17125737	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12548285	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	27518564	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	12548285	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	10103013	GOA
involved in negative regulation of translation in response to stress	IDA IDA: Inferred from direct assay	19332886	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	9122172	GOA
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	17125737	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	2646638	GOA
involved in rRNA transcription	IDA IDA: Inferred from direct assay	27518564	GOA
involved in rRNA transcription	IMP IMP: Inferred from mutant phenotype	15735021	GOA
involved in response to hormone	IDA IDA: Inferred from direct assay	10999833	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	10999833	GOA
involved in response to yeast	IDA IDA: Inferred from direct assay	12548285	GOA
involved in signaling	IDA IDA: Inferred from direct assay	2457905	GOA
involved in stress granule assembly	IDA IDA: Inferred from direct assay	20129916	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of angiogenin-PRI complex	IDA IDA: Inferred from direct assay	3470787	GOA
part of angiogenin-PRI complex	IPI IPI: Inferred from physical interaction	3470787	GOA
located in basement membrane	IDA IDA: Inferred from direct assay	15166501	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	23047679	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27518564	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	29748193	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	3663649	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	23047679	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10649442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANG Protein Structure

RnaseA

0
100
147 a.a.

Protein Preferred Names	Protein Names
angiogenin	RNase 5

ANG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANG	P03950	RNH1	Homo sapiens	P13489	Affinity Techniques	10413501
Intra	ANG	P03950	RNH1	Homo sapiens	P13489	Anti Tag CoIP	33961781
Intra	ANG	P03950	RNH1	Homo sapiens	P13489	Anti Tag CoIP	28514442
Intra	ANG	P03950	PCNA	Homo sapiens	P12004	Imaging	28777577
Intra	ANG	P03950	PCNA	Homo sapiens	P12004	Anti Bait CoIP	28777577
Intra	ANG	P03950	PLAUR	Homo sapiens	Q03405	IF	24457100
Intra	ANG	P03950	PLAUR	Homo sapiens	Q03405	Anti Bait CoIP	24457100
Intra	ANG	P03950	PLAUR	Homo sapiens	Q03405	PLA	24457100
Intra	ANG	P03950	ACTN2	Homo sapiens	P35609	FRET	15737636

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7503	Angiogenin Protein, Human	P03950 (Q25-P147)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700644	Angiogenin Protein, Human (His)	P03950 (D26-P147)	≥ 90%, as determined by reducing SDS-PAGE.

ANG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811036	ANG Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis 9	Amyotrophic Lateral Sclerosis Type 9 ALS9 Sclerosis, Lateral, Amyotrophic, Type Type 9
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic Lateral Sclerosis Type 4 ALS4 Amyotrophic Lateral Sclerosis 4 Dhmn With Upper Motor Neuron Signs Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs Neuronopathy, Distal Hereditary Motor, With Pyramidal Features Als 4 Distal Hereditary Motor Neuropathy With Pyramidal Features Amyotrophic Lateral Sclerosis Juvenile 4 Neuronopathy Distal Hereditary Motor With Pyramidal Features Sclerosis, Lateral, Amyotrophic, Type Type 4
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Als6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Autosomal Recessive Amyotrophic Lateral Sclerosis 6 Sclerosis, Lateral, Amyotrophic, Type Type 6 Amyotrophic Lateral Sclerosis 6
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13948	Angiotensin II human		99.98%	Unkown
HY-13948A	Angiotensin II human acetate		99.81%	Unkown
HY-B0561	Spironolactone		99.81%	Yes
HY-B0202	Irbesartan		99.95%	Yes
HY-B0935	Benzyl benzoate	Inhibitor	99.98%	Yes
HY-13948B	Angiotensin II human TFA		98.29%	Unkown
HY-B0202A	Irbesartan hydrochloride		/	Unkown
HY-B0202R	Irbesartan (Standard)		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99116	Faricimab	Inhibitor	97.97%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160187	AAA	Antagonist	99.52%	Phase 4
HY-P4073	ANG1005		98.83%	Phase 3
HY-137455	Terevalefim	Activator	99.37%	Phase 3
HY-177671	Zodasiran	Inhibitor	95.26%	Phase 3
HY-177671A	Zodasiran sodium	Inhibitor	/	Phase 3
HY-109041	Razuprotafib		98.0%	Phase 2
HY-147243	Ansornitinib	Inhibitor	98.23%	Phase 2
HY-124397	N-Acetylcolchinol phosphate	Inhibitor	/	Phase 2

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99546	Trebananib	Inhibitor	≥99.0%	Phase 3
HY-P99330	Vanucizumab	Inhibitor	95.12%	Phase 2
HY-P99510	Zansecimab	Inhibitor	≥95.0%	Phase 2
HY-P990689	Zifibancimig	Inhibitor	99.00%	Phase 2
HY-P99036	Nesvacumab	Inhibitor	99.11%	Phase 1
HY-P991663	AMG-780	Inhibitor	/	Phase 1
HY-P991415	ASKG-712	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (63)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12403	Talfirastide		99.91%	Yes
HY-P0216	A 779	Antagonist	99.55%	Unkown
HY-P1236	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse	Inhibitor	99.55%	Unkown
HY-15477	YS-49		99.98%	Unkown
HY-168438	ERBB agonist-1		99.16%	Unkown
HY-N0515	Ophiopogonin D		99.80%	Unkown
HY-151483	TK-129	Inhibitor	≥98.0%	Unkown
HY-12403A	Talfirastide acetate		99.76%	Yes
HY-P3136	TRV055		99.47%	Unkown
HY-13948F1	Angiotensin II human, FAM-labeled	Activator	99.58%	Unkown
HY-N7665	Prosaikogenin G		98.35%	Unkown
HY-P2983	Angiotensin-converting enzyme		/	Unkown
HY-P3136A	TRV055 hydrochloride	Agonist	98.88%	Unkown
HY-N2445	Flavokawain C		99.79%	Unkown
HY-P1415A	Norleual TFA		99.93%	Unkown
HY-13948BS	Angiotensin II human-13C6,15N TFA		99.46%	Unkown
HY-15477A	YS-49 monohydrate		99.56%	Unkown
HY-13948F	Biotin-Ahx-Angiotensin II human		99.86%	Unkown
HY-P10933	PRO20	Antagonist	99.16%	Unkown
HY-P1236A	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA	Inhibitor	99.32%	Unkown
HY-15778A	AVE 0991 sodium salt	Agonist	99.47%	Unkown
HY-N2666	5α-Hydroxycostic acid	Inhibitor	95.17%	Unkown
HY-15193B	EMD638683 (S-Form)	Inhibitor	99.72%	Unkown
HY-B0202S	Irbesartan-d4	Antagonist	99.46%	Unkown
HY-135795	1-Cyclohexyl-3-dodecyl urea	Inhibitor	98.0%	Unkown
HY-16707	CH 5450	Inhibitor	98.19%	Unkown
HY-172699A	DSPE-PEG3400-ANG		95.0%	Unkown
HY-B0561S4	Spironolactone-d6-1		99.26%	Unkown
HY-RS00684	ANG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W342283	Diminazene		/	Unkown
HY-109041A	Razuprotafib sodium		/	Unkown
HY-184265	Mito-Esculetin		/	Unkown
HY-102093A	ZD 7155		/	Unkown
HY-103247	EMD 66684	Antagonist	/	Unkown
HY-105506	EXP-7711	Antagonist	/	Unkown
HY-108120	L-162537	Inhibitor	/	Unkown
HY-114164E	Rabbit Thrombin		/	Unkown
HY-121313	Embusartan	Antagonist	/	Unkown
HY-129412	A-74273	Inhibitor	/	Unkown
HY-131162	Chymase	Activator	/	Unkown
HY-142694	DCN1-UBC12-IN-2	Inhibitor	/	Unkown
HY-160043	AL6 aptamer sodium		/	Unkown
HY-162729	LSD1-IN-34	Inhibitor	/	Unkown
HY-163859	LSD1-IN-33	Inhibitor	/	Unkown
HY-169026	DCN1-IN-2	Inhibitor	/	Unkown
HY-172698	DSPE-PEG1000-ANG		/	Unkown
HY-172699	DSPE-PEG2000-ANG		/	Unkown
HY-172700	DSPE-PEG5000-ANG		/	Unkown
HY-19165	CI-996	Antagonist	/	Unkown
HY-19200	RB-105	Inhibitor	/	Unkown
HY-B0202S2	Irbesartan-d6-1		/	Unkown
HY-P0216A	A-779 TFA	Antagonist	/	Unkown
HY-P10597	Angiotensin II type 1 receptor (181-187)	Activator	/	Unkown
HY-P11389	(Sar1,Gly8)-Angiotensin II	Antagonist	/	Unkown
HY-P1415	Norleual		/	Unkown
HY-P3545	5-Valine-angiotensin I	Activator	/	Unkown
HY-167886	GA 0113	Antagonist	/	Unkown
HY-180796	PKM2 agonist-1	Agonist	/	Unkown
HY-B0202AS	Irbesartan-d7 hydrochloride		/	Unkown
HY-B0202S3	Irbesartan-d7		/	Unkown
HY-RS16832	Ang Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23274	Ang Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24191	Agt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992323	BI-836880	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ANG	RGD	RGD:1594539
Mus musculus	ANG	MGD	MGI:88022
Others	ANG	NCBI