1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. Terevalefim

Terevalefim (Synonyms: ANG-3777)

Cat. No.: HY-137455
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Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.

For research use only. We do not sell to patients.

Terevalefim Chemical Structure

Terevalefim Chemical Structure

CAS No. : 1070881-42-3

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Description

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

In Vitro

Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human Umbilical Vein Epithelial Cells (HUVECs).
Concentration: 0.44, 1.78, and 7.1 μM.
Incubation Time: 24 to 48 hours.
Result: Dose-dependently inhibited cell proliferation.
In Vivo

Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].
Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[2].
Dosage: 40 mg/kg.
Administration: IP injection, once.
Result: Selectively phosphorylated the c-Met receptor and not other growth factor receptors.
Clinical Trial
Molecular Weight

176.24

Formula

C₉H₈N₂S

CAS No.
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Storage

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Terevalefim
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