Zifibancimig
Based on 1 Customer Validation
Zifibancimig (RO-7250284) is a monoclonal antibody against VEGF-A and Ang-2, with affinities of 4 pM and 2 pM, respectively. Zifibancimig has high stability, maintains target-binding capability under physiological stress and storage conditions, and is designed for sustained long-term ocular delivery via the Port Delivery implant device. Zifibancimig can be used in the research of retinal diseases.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 2517939-46-5
- Molecular Weight:47.921 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
Fab-G1-kappa
Human
VEGFA & ANGPT2
Zifibancimig (1 mg/mL) remains stable, retaining VEGF-A and Ang-2 binding activity, after ≤ 2 weeks of storage at 2-8 °C, pH 6.0 and ≤ 4 weeks of incubation at 37 °C, pH 7.4 under vitreous exposure-mimicking conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fab-G1-kappa
ELISA, FACS, Functional assay
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Loaded Zifibancimig on FAB2G biosensor, can bind VEGF121 Protein, Human (120 a.a, HY-P7420) with an affinity constant of <1.000E-11 M as determined in BLI assay. -
Loaded Zifibancimig on FAB2G biosensor, can bind Angiopoietin-2 Protein, Human (222a.a, HEK293, His, HY-P7510) with an affinity constant of 2.091E-09 M as determined in BLI assay. -
Flow cytometric analysis of 1X106 HeLa cells with Zifibancimig (HY-P990689, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2517939-46-5
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Appearance Liquid
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Molecular Weight 47.921 kDa
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Color Colorless to light yellow
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Synonyms
RO-7250284
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)