2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK Apoptosis
  3. Thrombin Ser/Thr Protease VEGFR Apoptosis
  4. Rabbit Thrombin

Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia.

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CAS No. : 9002-04-4

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Based on 7 publication(s) in Google Scholar

Other Forms of Rabbit Thrombin:

Rabbit Thrombin Related Antibodies

Top Publications Citing Use of Products

    Rabbit Thrombin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Feb;45(2):143-166.  [Abstract]

    Platelets were treated with Fc fragment, Thrombin (1 µg/mL; 2 h), EphB1‐Fc, Thrombin + EphB1‐Fc, mono EphB1, mono EphB1 + EphB1‐Fc, or EFNB1 Ab + EphB1‐Fc. Platelets without treatment served as controls. CD62P expression in activated platelets was tested by flow cytometry analysis. Representative flow cytometry analysis of CD62P expression is presented on the left. The right graph shows the percentage of CD62P+ platelets. Data were presented as the means ± SD, with n  =  3 per group.

    Rabbit Thrombin purchased from MedChemExpress. Usage Cited in: Mol Carcinog. 2024 Jul;63(7):1288-1302.  [Abstract]

    Effect of knockdown of KDM4E and combined overexpression of BICD1 on the proliferative activity of Thrombin (1 pM)-activated TNBC cells detected by EdU staining (scale bar: 50 μm).

    Rabbit Thrombin purchased from MedChemExpress. Usage Cited in: Mol Carcinog. 2024 Jul;63(7):1288-1302.  [Abstract]

    Effect of knockdown of KDM4E and combined overexpression of BICD1 on the invasive activity of Thrombin (1 pM)-activated TNBC cells detected by Transwell assay (scale bar: 50 μm). *p < 0.05 versus the sh-scramble group, #p < 0.05 versus the sh-KDM4E + oe-NC group, &p < 0.05 versus the blank group.

    Rabbit Thrombin purchased from MedChemExpress. Usage Cited in: Allergy. 2022 Jul;77(7):2104-2120.  [Abstract]

    Western blots for the HA tag on RRL-expressed IL-33 showing the Thrombin cleavage of human pro-IL-33 into the two main forms, ~18 and ~25 kDa, and the inhibition of these cleavage events by the Thrombin inhibitor Argatroban (50 μg/ml). Cleavage occurred in a time-dependent manner (15 min, 30 min, 1 h, 2 h and 4 h; 0.075 U Thrombin; 15 μL buffer) (A) and a dose-dependent manner (0.01875, 0.0375, 0.075, 0.15 and 0.3 U; RT for 1 h; 15 μL buffer) (B).

    Rabbit Thrombin purchased from MedChemExpress. Usage Cited in: Allergy. 2022 Jul;77(7):2104-2120.  [Abstract]

    L-33-dependent IL-5, IL-13 and IL-4 production by ST2+ CD4 cells incubated with or without Thrombin (50 pg RRL; 0.075 U Thrombin; RT for 1 h) and with or without a neutralizing hIL-33 mAb. The bars and error bars represent the mean ± SEM; *p < .05; **p < .01; ***p < .001.

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    Description

    Rabbit Thrombin is a serine protease. Rabbit Thrombin forms a covalent complex with antithrombin III and reversibly binds endothelial cell surface high-affinity sites. Rabbit Thrombin regulates VEGF and Ang-2, potentiates VEGF mitogenic activity and protects endothelial cells from apoptosis. Rabbit Thrombin can be used for the research of hindlimb ischemia[1][2].

    In Vitro

    Rabbit Thrombin forms a complex with Antithrombin III in rabbit whole blood in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Rabbit Thrombin Related Antibodies
    In Vivo

    Rabbit Thrombin undergoes slower clearance from rabbit circulation compared to active-site blocked Thrombin (HY-114164), with ~75% remaining in circulation at 1 minute[1].
    Rabbit Thrombin (500-15000 IU; intramuscular; single administration) promotes dose-dependent arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: New Zealand White (male, approximately 6-month-old, weight 3.0-4.0 kg, bilateral femoral artery surgical excision to induce hindlimb ischemia)[2]
    Dosage: 500 IU; 1500 IU; 5000 IU; 15,000 IU
    Administration: intramuscular; single administration
    Result: Induced a 30.2% increase in total collateral vessel area and length compared to control ischemic limbs.
    Doubled the arteriolar count per optical field in adductor muscle compared to control limbs.
    Increased saphenous artery peak enhancement by 100.9% compared to control limbs.
    Reduced time-to-peak enhancement significantly.
    Achieved a semiquantitative slope method perfusion score of 5.7, which was not significantly inferior to normal nonoperated limbs (score 6.5).
    Evoked a pronounced arteriogenic response in both treated and contralateral control limbs, with total collateral vessel area of 10,879 pixels (treated) and 10,384 pixels (control), compared to 5882 pixels in ischemic internal control limbs.
    Increased mean collateral diameter in both treated (2.77 pixels) and control (2.75 pixels) limbs compared to normal nonoperated subjects (2.66 pixels).
    Increased saphenous artery peak enhancement by 70-80% compared to normal subjects, with significantly delayed time-to-peak intervals.
    Achieved a semiquantitative perfusion score of 5.4, similar to normal limbs.
    Increased arteriolar counts in both treated and contralateral control limbs, but caused abundant inflammatory cell infiltration in the treated limb.
    Did not produce statistically significant increases in collateral vessel area or length compared to control limbs.
    CAS No.
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    [Rabbit Thrombin]
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    Rabbit Thrombin Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Rabbit Thrombin9002-04-4ThrombinSer/Thr ProteaseVEGFRApoptosisSerine proteasesSerine endopeptidasesThreonine proteasesVascular endothelial growth factor receptorPAR1Ang-2endothelial cellsrabbit hindlimb ischemia modelα5β1 integrinsantithrombin IIIhindlimb ischemiaαvβ3 integrinsVEGFInhibitorinhibitorinhibit

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