2. Metabolic Enzyme/Protease GPCR/G Protein Protein Tyrosine Kinase/RTK Epigenetics
  3. Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain
  4. Canine Thrombin

Canine Thrombin is a Canine serine protease that plays a central role in blood coagulation. Canine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Canine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Canine Thrombin activity increases significantly in paraoxon-induced status epilepticus.

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CAS No. : 9002-04-4

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Based on 7 publication(s) in Google Scholar

Other Forms of Canine Thrombin:

Canine Thrombin Related Antibodies

Top Publications Citing Use of Products

    Canine Thrombin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Feb;45(2):143-166.  [Abstract]

    Platelets were treated with Fc fragment, Thrombin (1 µg/mL; 2 h), EphB1‐Fc, Thrombin + EphB1‐Fc, mono EphB1, mono EphB1 + EphB1‐Fc, or EFNB1 Ab + EphB1‐Fc. Platelets without treatment served as controls. CD62P expression in activated platelets was tested by flow cytometry analysis. Representative flow cytometry analysis of CD62P expression is presented on the left. The right graph shows the percentage of CD62P+ platelets. Data were presented as the means ± SD, with n  =  3 per group.

    Canine Thrombin purchased from MedChemExpress. Usage Cited in: Mol Carcinog. 2024 Jul;63(7):1288-1302.  [Abstract]

    Effect of knockdown of KDM4E and combined overexpression of BICD1 on the proliferative activity of Thrombin (1 pM)-activated TNBC cells detected by EdU staining (scale bar: 50 μm).

    Canine Thrombin purchased from MedChemExpress. Usage Cited in: Mol Carcinog. 2024 Jul;63(7):1288-1302.  [Abstract]

    Effect of knockdown of KDM4E and combined overexpression of BICD1 on the invasive activity of Thrombin (1 pM)-activated TNBC cells detected by Transwell assay (scale bar: 50 μm). *p < 0.05 versus the sh-scramble group, #p < 0.05 versus the sh-KDM4E + oe-NC group, &p < 0.05 versus the blank group.

    Canine Thrombin purchased from MedChemExpress. Usage Cited in: Allergy. 2022 Jul;77(7):2104-2120.  [Abstract]

    Western blots for the HA tag on RRL-expressed IL-33 showing the Thrombin cleavage of human pro-IL-33 into the two main forms, ~18 and ~25 kDa, and the inhibition of these cleavage events by the Thrombin inhibitor Argatroban (50 μg/ml). Cleavage occurred in a time-dependent manner (15 min, 30 min, 1 h, 2 h and 4 h; 0.075 U Thrombin; 15 μL buffer) (A) and a dose-dependent manner (0.01875, 0.0375, 0.075, 0.15 and 0.3 U; RT for 1 h; 15 μL buffer) (B).

    Canine Thrombin purchased from MedChemExpress. Usage Cited in: Allergy. 2022 Jul;77(7):2104-2120.  [Abstract]

    L-33-dependent IL-5, IL-13 and IL-4 production by ST2+ CD4 cells incubated with or without Thrombin (50 pg RRL; 0.075 U Thrombin; RT for 1 h) and with or without a neutralizing hIL-33 mAb. The bars and error bars represent the mean ± SEM; *p < .05; **p < .01; ***p < .001.

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    Description

    Canine Thrombin is a Canine serine protease that plays a central role in blood coagulation. Canine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Canine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Canine Thrombin activity increases significantly in paraoxon-induced status epilepticus[1][2][3][4].

    IC50 & Target[1][3]

    PAR1

     

    MMP-3

     

    MMP-9

     

    In Vitro

    Canine Thrombin (100 nM; 72 h) induces degeneration in cultured intervertebral discs and promotes the production of MCP-1 and VEGF[1].
    Canine Thrombin (100 nM) induces the polarization of macrophages toward an M1-like phenotype by upregulating the expression of M1 markers and downregulating the expression of M2 markers[1].
    Canine Thrombin (0.1-1 U/mL; 12-48 h) upregulates the expressions of CCL22, MRC-1 (CD206), MMP9 and CD36 in macrophages[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Canine Thrombin Related Antibodies
    In Vivo

    Canine Thrombin plays a critical pro-inflammatory role in the mouse coccygeal puncture model, where it induces intervertebral disc degeneration, promotes angiogenesis, and drives M1 macrophage polarization[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    CAS No.
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    [Canine Thrombin]
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    Canine Thrombin Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Canine Thrombin9002-04-4ThrombinProtease Activated Receptor (PAR)MMPVEGFREpigenetic Reader DomainThrombin receptorsMatrix metalloproteinasesVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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