2. Metabolic Enzyme/Protease GPCR/G Protein Protein Tyrosine Kinase/RTK Epigenetics
  3. Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain
  4. Murine Thrombin

Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus.

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Murine Thrombin

Murine Thrombin Chemical Structure

CAS No. : 9002-04-4

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Murine Thrombin Related Antibodies

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Description

Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of MCP-1, MMP3 and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus[1][2][3][4].

IC50 & Target[1][3]

PAR1

 

MMP-3

 

MMP-9

 

In Vitro

Murine Thrombin (100 nM; 72 h) induces degeneration in cultured mouse intervertebral discs and promotes the production of MCP-1 and VEGF[1].
Murine Thrombin (100 nM) induces the polarization of mouse bone marrow-derived macrophages toward an M1-like phenotype by upregulating the expression of M1 markers and downregulating the expression of M2 markers[1].
Murine Thrombin (0.1-1 U/mL; 12-48 h) upregulates the expressions of CCL22, MRC-1 (CD206), MMP9 and CD36 in murine macrophages[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Murine Thrombin Related Antibodies
In Vivo

Murine Thrombin plays a critical pro-inflammatory role in the mouse coccygeal puncture model, where it induces intervertebral disc degeneration, promotes angiogenesis, and drives M1 macrophage polarization[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Murine Thrombin]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

SDS (251 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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Murine Thrombin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Murine Thrombin9002-04-4ThrombinProtease Activated Receptor (PAR)MMPVEGFREpigenetic Reader DomainThrombin receptorsMatrix metalloproteinasesVascular endothelial growth factor receptoroxidized low-density lipoprotein (oxLDL)fibrinogenProteinase-activated receptor 1 (PAR1)PAR4monocyte chemotactic protein-1 (MCP-1)pERK pathwaysecreted modular Ca2?-binding protein 1 (SMOC1)protein Cmatrix metalloproteinase 3 (MMP3)clotting cascadeInhibitorinhibitorinhibit

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