CI-996
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity.
For research use only. We do not sell to patients.
- CAS No.: 150438-02-1
- Formula: C27H22F3N7O3
- Molecular Weight:549.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Angiotensin Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
AT1 Receptor |
In Vitro
In isolated rabbit aorta CI-996 produces a concentration-dependent inhibition of Ang II-induced contraction and decreased the maximal contractile response to Ang II. CI-996 has no effect on the contractile responses to KCl, norepinephrine or endothelin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Orally administered CI-996 dose dependently loweres mean arterial blood pressure in conscious renal hypertensive rats, conscious sodium-depleted dogs, conscious sodium-depleted monkeys and conscious renal hypertensive monkeys[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 150438-02-1
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Molecular Weight 549.50
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Formula C27H22F3N7O3
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SMILES
O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CI-996 Related Classifications
HY-19165 Related Classifications
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